USPTO Patents Application 10551504

I

t

1

SEQUENCE LISTING

<110> Tsunoda, Hiroyuki
Nakano, Kiyotaka
Orita, Tetsuro
Tsuchiya, Masayuki
Hirata, Yuichi

<120> ANTI-MPL ANTIBODIES

<130> 14875-153US1

<150> PCT/JP2004/018506
<151> 2004-10-12

<150> JP 2003-415746
<151> 2003-12-12

<150> JP 2004-71763
<151> 2004-03-12

<150> JP 2004-248323
<151> 2004-08-27

<160> 308

<170> Patentin version 3.1

<210> 1

<211> 1572

<212> DNA

<213> Homo sapiens

<400> 1
atggactgga

cctggaggtt

cctctttgtg

gtggcagcag

gtgcagctgg

tgcagtctgg

acctgaggtg

aagaagcctg

tgcaaggctt

ctggatacac

cttcaccaac

tcctggatga

ggaaagggtc

ttgagtggat

gggacggatt

tatcctggag

gggaaattca

gggtcagagt

cacgattacc

gcggacgaat

gagctgagca

gcctgagatc

tgaggacacg

gccgtgtatt

gattactcgt

ttgcttactg

gggccaggga

accacggtca

ggatccggag

gtggtggatc

gggtggtgga

ggatcggata

ctctccctgc

ccgtcacccc

tggagagccg

gcctccatct

ctcctgcata

gtaatggcaa

cacttacttg

tattggttcc

ccacagctcc

tgatctatcg

gatgtccaac

cttgcctcag

ggcagtggat

caggcacagc

ttttacactg

aaaatcagca

10/551504
.X12 Rec'd PCT/PT; 29 SEP 2005

ctacaggtgt

ccagtcccag

60

gggcctcagt

gaaggtctcc

120

actgggtgag

gcagaggcct

180

atggagaaac

tatctacaat

240

ccacgagcac

agcctacatg

300

actgtgcgag

aggctatgat

360

ccgtctcttc

aggtggtggt

420

ttgtgatgac

tcagtctgca

480

cctgcaggtc

tagtaagagt

540

agcagaagcc

agggcagtct

600

gggtccctga

caggttcagt

660

gagtggaggc

tgaggatgtt

720

2

ggggtttatt

actgcatgca

acatatagaa

tatcctttta

cgttcggcca

agggaccaaa

780

ctggaaatca

aaggaggtgg

tggatcgggt

ggtggtggtt

cgggaggcgg

tggatcgcag

840

gtgcagctgg

tgcagtctgg

acctgaggtg

aagaagcctg

gggcctcagt

gaaggtctcc

900

tgcaaggctt

ctggatacac

cttcaccaac

tcctggatga

actgggtgag

gcagaggcct

960

ggaaagggtc

ttgagtggat

gggacggatt

tatcctggag

atggagaaac

tatctacaat

1020

gggaaattca

gggtcagagt

cacgattacc

gcggacgaat

ccacgagcac

agcctacatg

1080

gagctgagca

gcctgagatc

tgaggacacg

gccgtgtatt

actgtgcgag

aggctatgat

1140

gattactcgt

ttgcttactg

gggccaggga

accacggtca

ccgtctcttc

aggtggtggt

1200

ggatccggag

gtggtggatc

gggtggtgga

ggatcggata

ttgtgatgac

tcagtctgca

1260

ctctccctgc

ccgtcacccc

tggagagccg

gcctccatct

cctgcaggtc

tagtaagagt

1320

ctcctgcata

gtaatggcaa

cacttacttg

tattggttcc

agcagaagcc

agggcagtct

1380

ccacagctcc

tgatctatcg

gatgtccaac

cttgcctcag

gggtccctga

caggttcagt

1440

ggcagtggat

caggcacagc

ttttacactg

aaaatcagca

gagtggaggc

tgaggatgtt

1500

ggggtttatt

actgcatgca

acatatagaa

tatcctttta

cgttcggcca

agggaccaaa

1560

ctggaaatca

aa

1572

<210> 2

<211> 524

<212> PRT

<213> Homo sapiens

<400> 2

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly
15 10 15

Val Gin Ser Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys
20 25 30

Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
35 40 45

Thr Asn Ser Trp Met Asn Trp Val Arg Gin Arg Pro Gly Lys Gly Leu
50 55 60

Glu Trp Met Gly Arg He Tyr Pro Gly Asp Gly Glu Thr He Tyr Asn
65 70 75 80

3

Gly Lys Phe Arg Val Arg Val Thr lie Thr Ala Asp Glu Ser Thr Ser
85 90 95

Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
100 105 110

Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly
115 120 125

Gin Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
130 135 140

Gly Gly Ser Gly Gly Gly Gly Ser Asp He Val Met Thr Gin Ser Ala
145 150 155 160

Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser He Ser Cys Arg
165 170 175

Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp
180 185 190

Phe Gin Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu He Tyr Arg Met
195 200 205

Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser
210 215 220

Gly Thr Ala Phe Thr Leu Lys He Ser Arg Val Glu Ala Glu Asp Val
225 230 235 240

Gly Val Tyr Tyr Cys Met Gin His He Glu Tyr Pro Phe Thr Phe Gly
245 250 255

Gin Gly Thr Lys Leu Glu He Lys Gly Gly Gly Gly Ser Gly Gly Gly
260 265 270

Gly Ser Gly Gly Gly Gly Ser Gin Val Gin Leu Val Gin Ser Gly Pro
275 280 285

Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
290 295 300

4

Gly Tyr Thr Phe Thr Asn Ser Trp Met Asn Trp Val Arg Gin Arg Pro
305 310 315 320

Gly Lys Gly Leu Glu Trp Met Gly Arg lie Tyr Pro Gly Asp Gly Glu
325 330 335

Thr lie Tyr Asn Gly Lys Phe Arg Val Arg Val Thr lie Thr Ala Asp
340 345 350

Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu
355 360 365

Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe
370 375 380

Ala Tyr Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
385 390 395 400

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp lie Val Met
405 410 415

Thr Gin Ser Ala Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser
420 , 425 430

lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr
435 440 445

Tyr Leu Tyr Trp Phe Gin Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu
450 455 460

lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser
465 470 475 480

Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys He Ser Arg Val Glu
485 490 495

Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His He Glu Tyr Pro
500 505 510

Phe Thr Phe Gly Gin Gly Thr Lys Leu Glu He Lys
515 520

5

<210> 3

<211> 5

<212> PRT

<213> Mus musculus

<400> 3

Ser Ser Trp Met Asn
1 5

<210> 4

<211> 17

<212> PRT

<213> Mus musculus

<400> 4

Arg Thr Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys
15 10 15

Gly

<210> 5

<211> 13

<212> PRT

<213> Mus musculus

<400> 5

Gly Trp lie Leu Ala Asp Gly Gly Tyr Ser Phe Ala Tyr
15 10

<210> 6

<211> 5

<212> PRT

<213> Mus musculus

<400> 6

Ser Ser Trp Met Asn
1 5

<210> 7

<211> 17

<212> PRT

<213> Mus musculus

<400> 7

Arg lie Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys

6

10 15

Gly

<210> 8

<211> 9

<212> PRT

<213> Mus musculus

<400> 8

Gly Tyr Ala Asp Tyr Ser Phe Ala Tyr

<210> 9

<211> 5

<212> PRT

<213> Mus musculus

<400> 9

Ser Ser Trp Met Asn

<210> 10

<211> 17

<212> PRT

<213> Mus musculus

<400> 10

Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Tyr Asn Gly Lys Phe Lys
15 10 15

Gly

<210> 11

<211> 9

<212> PRT

<213> Mus musculus

<400> 11

Gly Phe Gly Asp Tyr Ser Phe Ala Tyr
1 5

<210> 12
<211> 5

7

<212>
<213>

PRT

Mus musculus

<400>

12

Ser Ser Trp Met Asn
1 5

<210> 13

<211> 17

<212> PRT

<213> Mus musculus

<400> 13

Arg lie Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys
15 10 15

Gly

<210> 14

<211> 9

<212> PRT

<213> Mus musculus

<400> 14

Gly Tyr Ala Asp Tyr Ser Phe Ala Tyr
1 5

<210> 15

<211> 5

<212> PRT

<213> Mus musculus

<400> 15

Arg Ser Trp Met Asn
1 5

<210> 16

<211> 17

<212> PRT

<213> Mus musculus

<400> 16

Arg lie Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys
15 10 15

8

Gly

<210> 17

<211> 9

<212> PRT

<213> Mus musculus

<400> 17

Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr
1 5

<210> 18

<211> 5

<212> PRT

<213> Mus musculus

<400> 18

Asn Ser Trp Met Asn
1 5

<210> 19

<211> 17

<212> PRT

<213> Mus musculus

<400> 19

Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Asn Asn Gly Lys Phe Lys
15 10 15

Gly

<210> 20

<211> 9

<212> PRT

<213> Mus musculus

<400> 20

Gly Tyr Gly Asp Tyr Ser Phe Ala Tyr
1 5

<210> 21

<211> 5

<212> PRT

<213> Mus musculus

9

<400> 21

Asn Tyr Trp Val Asn

<210> 22

<211> 17

<212> PRT

<213> Mus musculus

<400> 22

Arg lie His Pro Ser Asp Ser Glu Thr His Cys Asn Gin Lys Phe Lys
15 10 15

Arg

<210> 23

<211> 6

<212> PRT

<213> Mus musculus

<400> 23

Gly Gly Trp Phe Ala Tyr

<210> 24

<211> 5

<212> PRT

<213> Mus musculus

<400> 24

Ser Ser Trp Met Asn
1 5

<210> 25

<211> 17

<212> PRT

<213> Mus musculus

<400> 25

Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Asn Asn Gly Lys Phe Lys
15 10 15

Gly

10

<210> 26

<211> 9

<212> PRT

<213> Mus musculus

<400> 26

Gly Tyr Gly Asp Tyr Ser Phe Ala Tyr
1 5

<210> 27

<211> 5

<212> PRT

<213> Mus musculus

<400> 27

Thr Ser Trp Met Asn
1 5

<210> 28

<211> 17

<212> PRT

<213> Mus musculus

<400> 28

Arg lie Tyr Pro Gly Asp Gly Glu Ala Asn Tyr Asn Gly Lys Phe Lys
15 10 15

Gly

<210> 29

<211> 9

<212> PRT

<213> Mus musculus

<400> 29

Gly Tyr Gly Asp Tyr Ser Phe Ala Tyr
1 5

<210> 30

<211> 5

<212> PRT

<213> Mus musculus

<400> 30

Ser Ser Trp Met Asn

11

<210> 31

<211> 17

<212> PRT

<213> Mus musculus

<400> 31

Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Tyr Asn Gly Lys Phe Lys
15 10 15

Gly

<210> 32

<211> 9

<212> PRT

<213> Mus musculus

<400> 32

Gly Tyr Gly Asp Tyr Ser Phe Ala Tyr

<210> 33

<211> 5

<212> PRT

<213> Mus musculus

<400> 33

Arg Ser Trp Met Asn

<210> 34

<211> 17

<212> PRT

<213> Mus musculus

<400> 34

Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Tyr Asn Gly Lys Phe Lys
15 10 15

Gly

<210> 35
<211> 9

12

<212>
<213>

PRT

Mus musculus

<400>

35

Gly Asp Gly Asp Tyr Ser Phe Ala Tyr
1 5

<210> 36

<211>. 5

<212> PRT

<213> Mus musculus

<400> 36

Asn Ser Trp Met Asn
1 5

<210> 37

<211> 17

<212> PRT

<213> Mus musculus

<400> 37

Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe Arg
15 10 15

Val

<210> 38

<211> 9

<212> PRT

<213> Mus musculus

<400> 38

Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr
1 5

<210> 39

<211> 5

<212> PRT

<213> Mus musculus

<400> 39

Asp Tyr Trp Val Asn
1 5

13

<210> 40

<211> . 17

<212> PRT

<213> Mus musculus

<400> 40

Arg lie His Pro Tyr Asp Ser Glu Thr His Tyr Asn Gin Lys Phe Lys

10

15

Asn

<210> 41

<211> 6

<212> PRT

<213> Mus musculus

<400> 41

Gly Gly Trp Phe Ala Ser
1 5

<210> 42

<211> 5

<212> PRT

<213> Mus musculus

<400> 42

Asp Tyr Trp Met Asn
1 5

<210>

43

<211>

17

<212>

PRT

<213>

Mus

<400>

43

musculus

Arg lie His Pro Phe Asp Ser Glu Thr His Cys Ser Gin Lys Phe Lys
15 10 15

Asn

<210> 44

<211> 6

<212> PRT

<213> Mus musculus

14

<400> 44

Gly Gly Trp Phe Ala Tyr
1 5

<210> 45

<211> 5

<212> PRT

<213> Mus musculus

<400> 45

Asn Ser Trp Met Asn
1 5

<210> 46

<211> 17

<212> PRT

<213> Mus musculus

<400> 46

Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe Arg
15 10 15

Val

<210> 47

<211> 9

<212> PRT

<213> Mus musculus

<400> 47

Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr
1 5

<210> 48

<211> 5

<212> PRT

<213> Mus musculus

<400> 48

Asn Ser Trp Met Asn
1 5

<210> 49
<211> 17

15

<212> PRT

<213> Mus musculus

<400> 49

Arg lie Tyr Pro Gly Asp Gly Asp Thr lie Tyr Asn Gly Asn Phe Lys
15 10 15

Gly

<210> 50

<211> 9

<212> PRT

<213> Mus musculus

<400> 50

Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr
1 5

<210> 51

<211> 5

<212> PRT

<213> Mus musculus

<400> 51

Ser Tyr Thr Met Ser
1 5

<210>

52

<211>

17

<212>

PRT

<213>

Mus

<400>

52

musculus

Thr lie Ser Ser Gly Ser Ser Thr lie Tyr Tyr Ala Asp Thr Val Lys
15 10 15

Gly

<210> 53

<211> 6

<212> PRT

<213> Mus musculus

<400>

53

16

Arg Trp Phe Leu Asp Cys
1 5

<210> 54

<211> 5

<212> PRT

<213> Mus musculus

<400> 54

Ser Ser Trp Met Asn

<210> 55

<211> 17

<212> PRT

<213> Mus musculus

<400> 55

Arg lie Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys
15 10 15

Gly

<210> 56

<211> 9

<212> PRT

<213> Mus musculus

<400> 56

Ala Arg Lys Thr Ser Trp Phe Ala Tyr

<210> 57

<211> 6

<212> PRT

<213> Mus musculus

<400> 57

Ser Asp Tyr Ala Trp Ser
1 5

<210> 58

<211> 16

<212> PRT

<213> Mus musculus

17

<400> 58

Tyr lie Thr Tyr Ser Gly Tyr Ser lie Tyr Asn Pro Ser Leu Lys Ser
15 10 15

<210> 59

<211> 7

<212> PRT

<213> Mus musculus

<400> 59

Gly Tyr Asp Asn Met Asp Tyr
1 5

<210> 60

<211> 16

<212> PRT

<213> Mus musculus

<400> 60

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 61

<211> 7

<212> PRT

<213> Mus musculus

<400> 61

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 62

<211> 9

<212> PRT

<213> Mus musculus

<400> 62

Met Gin His Leu Glu Tyr Pro Phe Thr
1 5

<210> 63

<211> 16

<212> PRT

<213> Mus

musculus

<400> 63

18

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 64

<211> 7

<212> PRT

<213> Mus musculus

<400> 64

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 65

<211> 9

<212> PRT

<213> Mus musculus

<400> 65

Met Gin His Leu Glu Tyr Pro Tyr Thr

<210> 66

<211> 16

<212> PRT

<213> Mus musculus

<400> 66

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
1 5 . 10 15

<210> 67

<211> 7

<212> PRT

<213> Mus musculus

<400> 67

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 68

<211> 9

<212> PRT

<213> Mus musculus

<400> 68

Met Gin His Leu Glu Tyr Pro Tyr Thr

19

<210> 69

<211> 16

<212> PRT

<213> Mus musculus

<400> 69

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr

10

15

<210> 70

<211> 7

<212> PRT

<213> Mus musculus

<400> 70

Arg Met Ser Asn Leu Ala Ser

<210> 71

<211> 9

<212> PRT

<213> Mus musculus

<400> 71

Met Gin His Leu Glu Tyr Pro Tyr Thr

<210> 72

<211> 16

<212> PRT

<213> Mus musculus

<400> 72

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 73

<211> 7

<212> PRT

<213> Mus musculus

<400> 73

Arg Met Ser Asn Leu Ala Ser
1 5

20

<210> 74

<211> 9

<212> PRT

<213> Mus musculus

<400> 74

Met Gin His Leu Glu Tyr Pro Tyr Thr

<210> 75

<211> 16

<212> PRT

<213> Mus musculus

<400> 75

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 76

<211> 7

<212> PRT

<213> Mus musculus

<400> 76

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 77

<211> 9

<212> PRT

<213> Mus musculus

<400> 77

Met Gin His Leu Glu Tyr Pro Tyr Thr

<210> 78

<211> 16

<212> PRT

<213> Mus musculus

<400> 78

Arg Ser Ser Lys Ser Leu Leu Tyr Ser Asn Gly Asn lie Tyr Leu Tyr
15 10 15

<210> 79

21

<211> 7

<212> PRT

<213> Mus musculus

<400> 79

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 80

<211> 9

<212> PRT

<213> Mus musculus

<400> 80

Met Gin His Leu Glu Tyr Pro Tyr Thr
1 5

<210> 81

<211> 16

<212> PRT

<213> Mus musculus

<400> 81

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 82

<211> 7

<212> PRT

<213> Mus musculus

<400> 82

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 83

<211> 9

<212> PRT

<213> Mus musculus

<400> 83

Met Gin His Leu Glu Tyr Pro Tyr Thr
1 5

<210>
<211>

84
16

22

<212> PRT

<213> Mus musculus

<400> 84

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 85

<211> 7

<212> PRT

<213> Mus musculus

<400> 85

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 86

<211> 9

<212> PRT

<213> Mus musculus

<400> 86

Met Gin His Val Glu Tyr Pro Tyr Thr
1 5

<210> 87

<211> 16

<212> PRT

<213> Mus musculus

<400> 87

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 88

<211> 7

<212> PRT

<213> Mus musculus

<400> 88

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 89

<211> 9

<212> PRT

<213> Mus musculus

23

<400> 89

Met Gin His Leu Glu Tyr Pro Tyr Thr
1 5

<210> 90

<211> 16

<212> PRT

<213> Mus musculus

<400> 90

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 91

<211> 7

<212> PRT

<213> Mus musculus

<400> 91

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 92

<211> 9

<212> PRT

<213> Mus musculus

<400> 92

Met Gin His Leu Glu Tyr Pro Tyr Thr
1 5

<210>

93

<211>

16

<212>

PRT

<213>

Mus

<400>

93

musculus

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 94

<211> 7

<212> PRT

<213> Mus musculus

<400> 94

24

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 95

<211> 9

<212> PRT

<213> Mus musculus

<400> 95

Met Gin His lie Glu Tyr Pro Phe
1 5

<210> 96

<211> 16

<212> PRT

<213> Mus musculus

<400> 96

Arg Ser Ser Lys Ser Leu Leu Tyr
1 5

<210> 97

<211> 7

<212> PRT

<213> Mus musculus

<400> 97

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 98

<211> 9

<212> PRT

<213> Mus musculus

<400> 98

Met Gin His Leu Glu Tyr Pro Tyr
1 5

<210> 99

<211> 16

<212> PRT

<213> Mus musculus

<400> 99

Arg Ser Ser Lys Ser Leu Leu Tyr

Thr

Ser Asn Gly Asn Thr Tyr Leu Tyr
10 15

Thr

Ser Asn Gly Asn lie Tyr Leu Tyr

25

10 15

<210> 100

<211> 7

<212> PRT

<213> Mus musculus

<400> 100

Arg Met Ser Asn Leu Ala Ser

<210> 101

<211> 9

<212> PRT

<213> Mus musculus

<400> 101

Met Gin His Leu Glu Tyr Pro Tyr Thr

<210> 102

<211> 16

<212> PRT

<213> Mus musculus

<400> 102

Arg Ser Ser Lys Ser Leu Leu His Asn Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 103

<211> 7

<212> PRT

<213> Mus musculus

<400> 103

Arg Met Ser Asn Leu Ala Ser

<210> 104

<211> 9

<212> PRT

<213> Mus musculus

<400> 104

Met Gin His lie Glu Tyr Pro Phe Thr
1 5

26

<210> 105

<211> 16

<212> PRT

<213> Mus musculus

<400> 105

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 106

<211> 7

<212> PRT

<213> Mus musculus

<400> 106

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 107

<211> 9

<212> PRT

<213> Mus musculus

<400> 107

Met Gin His Leu Glu Tyr Pro Tyr Thr
1 5

<210> 108

<211> 15

<212> PRT

<213> Mus musculus

<400> 108

Arg Ala Ser Glu Ser Val Glu Tyr Tyr Gly Thr Ser Leu Met Gin
15 10 15

<210> 109

<211> 7

<212> PRT

<213> Mus musculus

<400> 109

Gly Ala Ser Asn Val Glu Ser
1 5

27

<210> 110 .

<211> 9

<212> PRT

<213> Mus musculus

<4'00> 110

Gin Gin Ser Arg Lys Val Pro Trp Thr
1 • 5

<210> 111

<211> 11

<212> PRT

<213> Mus musculus

<400> 111

Lys Ala Ser Gin Asn Val Gly Asn lie lie Ala
15 10

<210> 112

<211> 7

<212> PRT

<213> Mus musculus

<400> 112

Leu Ala Ser Tyr Arg Tyr Ser
1 5

<210> 113

<211> 9

<212> PRT

<213> Mus musculus

<400> 113

Gin Gin Tyr Ser Ser Ser Pro Leu Thr
1 5

<210> 114

<211> 12

<212> PRT

<213> Mus musculus

<400> 114

Ser Ala Ser Ser Ser Val Ser Ser Ser His Leu Tyr
15 10

<210>
<211>

115
7

28

<212> PRT

<213> Mus musculus

<400> 115

Ser Thr Ser Asn Leu Ala Ser
1 5

<210> 116

<211> 9

<212> PRT

<213> Mus musculus

<400> 116

His Gin Trp Ser Ser Tyr Pro Trp Thr
1 5

<210> 117

<211> 354

<212> DNA

<213> Mus musculus

<400> 117
caggttcagc

tgcagcagtc

tggacctgag

ctggtgaagc

ctggggcctc

agtgaagatt

60

tcctgcaagg

cttctggcta

tgcattcact

aactcctgga

tgaactgggt

gaagcagagg

120

cctggaaagg

gtcttgagtg

gattggacgg

atttatcctg

gagatggaga

aactatctac

180

aatgggaaat

tcagggtcaa

ggccacactg

actgcagaca

aatcctccag

cacagcctac

240

atggatatca

gcagcctgac

atctgaggac

tctgcggtct

acttctgtgc

aagaggctat

300

gatgattact

cgtttgctta

ctggggccaa

gggactctgg

tcactgtctc

tgca

354

<210> 118

<211> 118

<212> PRT

<213> Mus musculus

<400> 118

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys He Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp He
35 40 45

29

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe
50 55 60

Arg Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80

Met Asp lie Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 - 95

Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala
115

<210> 119
<211> 336
<212> DNA
<213> Mus musculus

<400> 119

gatattgtga tgactcaggc tgcaccctct atacctgtca ctcctggaga gtcagtatcc 60

atctcctgta ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg 12 0

ttcctgcaga ggccaggcca gtctcctcaa ctcctgatat atcggatgtc caaccttgcc 180

tcaggagtcc cagataggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc 24 0

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatat agaatatcct 300

tttacgttcg gatcggggac caagctggaa ataaaa 336

<210> 120

<211> 112

<212> PRT

<213> Mus musculus

<400> 120

Asp He Val Met Thr Gin Ala Ala Pro Ser He Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser He Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

30

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

lie Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 121
'<211> 762
<212> DNA

<213> Mus

musculus

<400> 121
atggaatggc

ctttgatctt

tctcttcctc

ctgtcaggaa

ctgcaggtgt

ccactcccag

gttcagctgc

agcagtctgg

acctgagctg

gtgaagcctg

gggcctcagt

gaagatttcc

tgcaaggctt

ctggctatgc

attcactaac

tcctggatga

actgggtgaa

gcagaggcct

ggaaagggtc

ttgagtggat

tggacggatt

tatcctggag

atggagaaac

tatctacaat

gggaaattca

gggtcaaggc

cacactgact

gcagacaaat

cctccagcac

agcctacatg

gatatcagca

gcctgacatc

tgaggactct

gcggtctact

tctgtgcaag

aggctatgat

gattactcgt

ttgcttactg

gggccaaggg

actctggtca

ctgtctctgc

aggtggtggt

ggttcggata

ttgtgatgac

tcaggctgca

ccctctatac

ctgtcactcc

tggagagtca

gtatccatct

cctgtaggtc

tagtaagagt

ctcctgcata

gtaatggcaa

cacttacttg

tattggttcc

tgcagaggcc

aggccagtct

cctcaactcc

tgatatatcg

gatgtccaac

cttgcctcag

gagtcccaga

taggttcagt

ggcagtgggt

caggaactgc

tttcacactg

agaatcagta

gagtggaggc

tgaggatgtg

ggtgtttatt

actgtatgca

acatatagaa

tatcctttta

cgttcggatc

ggggaccaag

ctggaaataa

aa

60
120
180
240
300
360
420
480
540
600
660
720
762

<210> 122

<211> 254

<212> PRT

<213> Mus musculus

<400> 122

31

Met Glu Trp Pro Leu lie Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly
15 10 15

Val His Ser Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys
20 25 30

Pro Gly Ala Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe
35 40 45

Thr Asn Ser Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu
50 55 60

Glu Trp lie Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn
65 70 75 80

Gly Lys Phe Arg Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser
85 90 95

Thr Ala Tyr Met Asp lie Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
100 105 110

Tyr Phe Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly
115 120 125

Gin Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Asp lie
130 135 140

Val Met Thr Gin Ala Ala Pro Ser lie Pro Val Thr Pro Gly Glu Ser
145 150 155 160

Val Ser He Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly
165 170 175

Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser Pro Gin
180 185 190

Leu Leu He Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg
195 200 205

Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg He Ser Arg
210 215 220

32

Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His He Glu
225 230 235 240

Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu He Lys
245 250

<210> 123

<211> 635

<212> PRT

<213> Homo sapiens

<400> 123

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala
15 10 15

Pro Gin Asn Leu Ala Gin Val Ser Ser Gin Asp Val Ser Leu Leu Ala
20 25 30

Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu
35 40 45

Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gin
50 55 60

Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser
65 70 75 80

Ser Gin Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys Gin Phe Pro
85 90 95

Asp Gin Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu Trp Val Lys
100 105 110

Asn Val Phe Leu Asn Gin Thr Arg Thr Gin Arg Val Leu Phe Val Asp
115 120 125

Ser Val Gly Leu Pro Ala Pro Pro Ser He lie Lys Ala Met Gly Gly
130 135 140

Ser Gin Pro Gly Glu Leu Gin He Ser Trp Glu Glu Pro Ala Pro Glu
145 150 155 160

He Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro
165 170 175

33

Lys Asn Ser Thr Gly Pro Thr Val lie Gin Leu lie Ala Thr Glu Thr
180 185 190

Cys Cys Pro Ala Leu Gin Arg Pro His Ser Ala Ser Ala Leu Asp Gin
195 200 205

Ser Pro Cys Ala Gin Pro Thr Met Pro Trp Gin Asp Gly Pro Lys Gin
210 215 220

Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser
225 230 235 240

Cys Leu lie Ser Gly Leu Gin Pro Gly Asn Ser Tyr Trp Leu Gin Leu
245 250 255

Arg Ser Glu Pro Asp Gly lie Ser Leu Gly Gly Ser Trp Gly Ser Trp
260 265 270

Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala Leu Gly
275 280 285

Leu Gin Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gin Trp Gin
290 295 300

Gin Gin Asp His Ala Ser Ser Gin Gly Phe Phe Tyr His Ser Arg Ala
305 310 315 320

Arg Cys Cys Pro Arg Asp Arg Tyr Pro lie Trp Glu Asn Cys Glu Glu
325 330 335

Glu Glu Lys Thr Asn Pro Gly Leu Gin Thr Pro Gin Phe Ser Arg Cys
340 345 350

His Phe Lys Ser Arg Asn Asp Ser lie lie His lie Leu Val Glu Val
355 360 365

Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser Pro Phe Trp
370 375 380

He His Gin Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu
385 390 395 400

34

He Ser Ser Gly His Leu Glu Leu Glu Trp Gin His Pro Ser Ser Trp
405 410 415

Ala Ala Gin Glu Thr Cys Tyr Gin Leu Arg Tyr Thr Gly Glu Gly His
420 425 430

Gin Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr
435 440 445

Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gin Leu Arg Ala Arg
450 455 460

Leu Asn Gly Pro Thr Tyr Gin Gly Pro Trp Ser Ser Trp Ser Asp Pro
465 470 475 480

Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp He Ser Leu Val Thr
485 490 495

Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu
500 505 510

Leu Arg Trp Gin Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu
515 520 525

Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gin Tyr Leu Arg
530 535 540

Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys
545 550 555 560

Glu Glu Val Glu Pro Ser Leu Leu Glu He Leu Pro Lys Ser Ser Glu
565 570 575

Arg Thr Pro Leu Pro Leu Cys Ser Ser Gin Ala Gin Met Asp Tyr Arg
580 585 590

Arg Leu Gin Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro
595 600 605

Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His He Ala Asn His
610 615 620

35

Ser Tyr Leu Pro Leu Ser Tyr Trp Gin Gin Pro

630 635

625

<z lU >

<211>

122

<212>

PRT

<213>

Mus musciilus

<400>

124

Gin Val

Gin Leu Gin

1

5

10 15

Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg Thr Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Arg Gly Trp lie Leu Ala Asp Gly Gly Tyr Ser Phe Ala Tyr Trp
100 105 110

Gly Gin Gly Thr Leu Val Thr Val Ser Ala

120

115

<210>

125

<211>

112

<212>

PRT

<213>

Mus musculus

<400>

125

Asp lie

Val Met Thr

1

5

10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

36

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly lie Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Phe Thr Phe Gly Thr Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 126

<211> 118

<212> PRT

<213> Mus musculus

<400> 126

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly. Lys Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80

He Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Arg Gly Tyr Ala Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

37

Leu Val Thr Val Ser Ala

T 1

J. J-Zj

<210>

127

<211>

112

<212>

PRT

<213>

Mus musculus

<400>

127

Asp lie Val Met Thr Gin Ala Ala Pro Ser Val Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 128

<211> 118

<212> PRT

<213> Mus mUsculus

<400> 128

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

38

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Tyr Asn Gly Lys Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Arg Gly Phe Gly Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala

115

<210>

129

<211>

112

<212>

PRT

<213>

Mus musculus

<400>

129

Asp lie Val Met Thr Gin Ala Ala Pro Ser Val Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Ala Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Thr Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

39

<210> 130

<211> 118

<212> PRT

<213> Mus musculus

<400> 130

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Ser Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Ser Gly Tyr Ala Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala

115

<210>

131

<211>

112

<212>

PRT

<213>

Mus musculus

<400>

131

Asp lie Val Met Thr Gin Ala Ala Pro Ser Val Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

40

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

<210>

132

<211>

118

<212>

PRT

<213>

Mus musculus

<400>

132

Gin Val

Gin Leu Gin

1

5

10 15

Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Arg Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Ser Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala
115

<210> 133

41

<211> 112
<212> PRT
<213> Mus musculus

<400> 133

Asp lie Val Met Thr Gin Ala Ala Pro Ser Val Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 134

<211> 118

<212> PRT

<213> Mus musculus

<400> 134

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys lie Ser Cys Arg Ala Phe Gly Tyr Ala Phe Ser Asn Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Asn Asn Gly Lys Phe
50 55 60

42

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Arg Gly Tyr Gly Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala
115

<210>

135

<211>

112

<212>

PRT

<213>

Mus

musculus

<400>

135

Asp lie

Val

Met Thr

1

5

Glu Ser

Val

Ser lie

20

10 15

25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu He Lys
100 105 110

<210> 136

<211> 115

<212> PRT

<213> Mus musculus

<400> 136

43

Gin Val Gin Leu Gin Gin Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Tyr
20 25 30

Trp Val Asn Trp Val Lys Gin Arg Pro Gly Arg Gly Leu Glu Trp lie
35 40 45

Gly Arg lie His Pro Ser Asp Ser Glu Thr His Cys Asn Gin Lys Phe
50 55 60

Lys Arg Lys Ala Thr Leu Thr Val Asn Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80

lie Gin Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95

Thr Ser Gly Gly Trp Phe Ala Tyr Trp Gly Gin Gly Thr Leu Val Thr
100 105 110

Val Ser Ala
115

<210>

137

<211>

112

<212>

PRT

<213>

Mus musculus

<400>

137

Asp lie

Val Met Thr

1

5

10

15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Ser
20 25 30

Asn Gly Asn lie Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
SO 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg He

44

65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 138

<211> 118

<212> PRT

<213> Mus musculus

<400> 138

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Asn Asn Gly Lys Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Arg Gly Tyr Gly Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala
115

<210> 139

<211> 112

<212> PRT

<213> Mus musculus

<400>

139

45

Asp He Val Met Thr Gin Ala Ala Pro Ser Val Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser He Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu He Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Ala Phe Thr Leu Arg He
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu He Lys
100 105 110

<210> 140

<211> 118

<212> PRT

<213> Mus musculus

<400> 140

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys He Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Thr Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp He
35 40 45

Gly Arg He Tyr Pro Gly Asp Gly Glu Ala Asn Tyr Asn Gly Lys Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Ser Ala Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

46

Ala Arg Gly Tyr Gly Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala

115

<210>

141

<211>

112

<212>

PRT

<213>

Mus musculus

<400>

141

Asp lie Val Met Thr Gin Ala Ala Pro Ser Val Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser He Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Met Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu He Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Val Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu He Lys
100 105 110

<210> 142

<211> 118

<212> PRT

<213> Mus musculus

<400> 142

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys He Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser

47

20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Pro Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Tyr Asn Gly Lys Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Val Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Arg Gly Tyr Gly Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala

115

<210>

143

<211>

112

<212>

PRT

<213>

Mus musculus

<400>

143

Asp lie Val Met Thr Gin Ala Ala Pro Ser Val Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

48

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 144

<211> 118

<212> PRT

<213> Mus musculus

<400> 144

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Leu Asn Pro Gly Ala
15 10 15

Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Arg Ser
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr Asn Tyr Asn Gly Lys Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr
65 70 75 80

Met Gin Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Arg Gly Asp Gly Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala

115

<210>

145

<211>

112

<212>

PRT

<213>

Mus musculus

<400>

145

Asp lie

Val Met Thr

1

5

10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser

49

20

25

30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 146

<211> 115

<212> PRT

<213> Mus musculus

<400> 146

Gin Val Gin Leu Gin Gin Pro Gly Thr Glu Leu Val Arg Pro Gly Ala
15 10 15

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30

Trp Val Asn Trp Val Lys Gin Arg Pro Gly Arg Gly Leu Glu Trp lie
35 40 45

Gly Arg lie His Pro Tyr Asp Ser Glu Thr His Tyr Asn Gin Lys Phe
50 55 60

Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80

lie Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95

Ala Ser Gly Gly Trp Phe Ala Ser Trp Gly Gin Gly Thr Leu Val Thr
100 105 110

50

Val Ser Ala
115

<210> 147
<211> 112
<212> PRT

<213> Mus musculus

I.

<400> 147

Asp He Val Met Thr Gin Ala Ala Pro Ser Val Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser He Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu He Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Thr He
65 70 75 80

Ser Ser Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu He Lys
100 105 110

<210> 148

<211> 115

<212> PRT

<213> Mus musculus

<400> 148

Gin Val Gin Leu Gin Gin Pro Gly Ala Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr
20 25 30

Trp Met Asn Trp Val Lys Gin Arg Pro Gly Arg Gly Leu Glu Trp He
35 40 45

51

Gly Arg lie His Pro Phe Asp Ser Glu Thr His Cys Ser Gin Lys Phe
50 55 60

Lys Asn Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Asn Thr Ala Tyr
65 70 75 80

lie Gin Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys
85 90 95

Ser Ser Gly Gly Trp Phe Ala Tyr Trp Gly Gin Gly Thr Leu Val Thr
100 105 110

Val Ser Ala

115

<210>

149

<211>

112

<212>

PRT

<213>

Mus musculus

<400>

149

Asp lie Val Met Thr Gin Ala Ala Pro Ser Val Ser Val Thr Pro Gly
15 10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu Tyr Ser
20 25 30

Asn Gly Asn lie Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu He Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys He
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

52

<210> 150

<211> 118

<212> PRT

<213> Mus musculus

<400> 150

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe Thr Asn Ser
20 25 30

Trp Met Asn Trp Val Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe
50 55 60

Arg Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr
65 70 75 80

Met Glu lie Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 90 95

Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala
115

<210> 151

<211> 112

<212> PRT

<213> Mus musculus

<400> 151

Asp lie Val Met Thr Gin Ala Ala Pro Ser Val Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Asn
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

53

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

lie Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 152

<211> 118

<212> PRT

<213> Mus musculus

<400> 152

Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys Pro Gly Ala
15 10 15

Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe Ser Asn Ser
20 25 30

Trp Met Asn Trp Val Asn Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Asp Thr lie Tyr Asn Gly Asn Phe
50 55 60

Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser lie Ala Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys
85 ' 90 95

Thr Ser Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Leu Val Thr Val Ser Ala
115

<210> 153

54

<211> 112
<212> PRT
<213> Mus musculus

<400> 153

Asp lie Val Met Thr Gin Ala Ala Pro Ser Leu Pro Val Thr Pro Gly
15 10 15

Glu Ser Val Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

Leu Glu Tyr Pro Tyr Thr Phe Gly Ser Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 154

<211> 423

<212> DNA

<213> Mus musculus

<220>

<221> CDS

<222> (1) . . (423)

<400> 154

atg gtt ctt gcc age tct acc acc age ate cac aee atg ctg ete ctg 48
Met Val Leu Ala Ser Ser Thr Thr Ser lie His Thr Met Leu Leu Leu
15 10 15

cte ctg atg ctg gee cag ccg gee atg geg gaa gtg aag ctg gtg gag 96
Leu Leu Met Leu Ala Gin Pro Ala Met Ala Glu Val Lys Leu Val Glu
20 25 30

tct ggg gga ggc tta gtg aag cct gga ggg tee egg aaa etc tec tgt
Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys
35 40 45

144

55

gca gcc tct gga ttc act ttc agt age tat acc atg tct tgg gtt cgc 192
Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser Trp Val Arg
50 55 60

cag act ccg gcg aag agg ctg gag tgg gtc gca acc att agt agt ggc 24 0

Gin Thr Pro Ala Lys Arg Leu Glu Trp Val Ala Thr lie Ser Ser Gly
65 70 75 80

agt agt acc ate tac tat gca gac aca gtg aag ggc cga ttc acc ate 288
Ser Ser Thr lie Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr lie
85 90 95

tec aga gac aat gee aag aac acc ctg ttc ctg caa atg ace agt eta 33 6

Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Gin Met Thr Ser Leu
100 105 110

agg tct gag gac aca gee atg tat tac tgt gca agg aga tgg ttt ctt 3 84

Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Trp Phe Leu
115 120 125

gac tgc tgg ggc caa ggc acc act etc aca gtc tec teg 423
Asp Cys Trp Gly Gin Gly Thr Thr Leu Thr Val Ser Ser
130 135 140

<210> 155

<211> 141

<212> PRT

<213> Mus musculus

<400> 155

Met Val Leu Ala Ser Ser Thr Thr Ser lie His Thr Met Leu Leu Leu
15 10 15

Leu Leu Met Leu Ala Gin Pro Ala Met Ala Glu Val Lys Leu Val Glu
20 25 30

Ser Gly Gly Gly Leu Val Lys Pro Gly Gly Ser Arg Lys Leu Ser Cys
35 40 45

Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Thr Met Ser Trp Val Arg
50 55 60

Gin Thr Pro Ala Lys Arg Leu Glu Trp Val Ala Thr lie Ser Ser Gly
65 70 75 80

Ser Ser Thr lie Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr lie
85 90 95

56

Ser Arg Asp Asn Ala Lys Asn Thr Leu Phe Leu Gin Met Thr Ser Leu
100 105 110

Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg Arg Trp Phe Leu
115 120 125

Asp Cys Trp Gly Gin Gly Thr Thr Leu Thr Val Ser Ser
130 135 140

<210>

156

<211>

357

<212>

DNA

<213>

Mus

itiusculus

<220>

<221>

CDS

<222>

(1) .

. . (357)

<400>

156

gat att gtg etc acc caa tct cca get tct ttg get gtg tct eta ggg 48
Asp lie Val Leu Thr Gin Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
15 10 15

cag agt gtc acc ate tec tge aga gcc agt gaa agt gtt gaa tat tat 96
Gin Ser Val Thr lie Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30

ggc act agt tta atg cag tgg tac caa cag aaa cca gga cag cca ccc 144
Gly Thr Ser Leu Met Gin Trp Tyr Gin Gin Lys Pro Gly Gin Pro Pro
35 40 45

aaa etc etc ate tat ggt gea tec aac gta gaa tct ggg gtc eet gee 192
Lys Leu Leu lie Tyr Gly Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60

agg ttt agt ggc agt ggg tct ggg aca gae ttc age etc aac ate cat 240
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn He His
65 70 75 80

cct gtg gag gag gat gat att gca atg tat ttc tgt cag caa agt agg 288
Pro Val Glu Glu Asp Asp He Ala Met Tyr Phe Cys Gin Gin Ser Arg
85 90 95

aag gtt ccg tgg acg ttc ggt gga ggc ace aag etg gaa ata aag gae 336
Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu He Lys Asp
100 105 110

tac aag gat gae gae gat aag 357
Tyr Lys Asp Asp Asp Asp Lys
115

<210> 157

57

<211> 119
<212> PRT
<213> Mus musculus

<400> 157

Asp He Val Leu Thr Gin Ser Pro Ala Ser Leu Ala Val Ser Leu Gly
15 10 15

Gin Ser Val Thr He Ser Cys Arg Ala Ser Glu Ser Val Glu Tyr Tyr
20 25 30

Gly Thr Ser Leu Met Gin Trp Tyr Gin Gin Lys Pro Gly Gin Pro Pro
35 40 45

Lys Leu Leu He Tyr Gly Ala Ser Asn Val Glu Ser Gly Val Pro Ala
50 55 60

Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn He His
65 70 75 80

Pro Val Glu Glu Asp Asp He Ala Met Tyr Phe Cys Gin Gin Ser Arg
85 90 95

Lys Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu He Lys Asp
100 105 110

Tyr Lys Asp Asp Asp Asp Lys
115

<210>

158

<211>

432

<212>

DNA

<213>

Mus

musculus

<220>

<221>

CDS

<222>

(1) .

. . (432)

<400>

158

atg gtt ctt gcc age tct acc acc age ate cac acc atg ctg etc ctg 48

Met Val Leu Ala Ser Ser Thr Thr Ser He His Thr Met Leu Leu Leu
15 10 15

etc ctg atg ctg gcc cag ccg gcc atg gcg cag gtt cag etc cag caa 96

Leu Leu Met Leu Ala Gin Pro Ala Met Ala Gin Val Gin Leu Gin Gin
20 25 30

tct gga ect gag ctg gtg aag ect ggg gcc tea gtg aag att tec tge

144

58

Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys lie Ser Cys
35 40 45

aag get tct ggc tat gca ttc agt age tec tgg atg aac tgg atg aag 192
Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser Trp Met Asn Trp Met Lys
50 55 60

cag agg cot gga aag ggt ctt gag tgg att ggg egg att tat cct gga 240
Gin Arg Pro Gly Lys Gly Leu Glu Trp lie Gly Arg lie Tyr Pro Gly
65 70 75 • 80

gat gga gat act aac tac aat ggg aag ttc aag ggc aag gee aca ctg 288
Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu
85 90 95

act gca gae aaa tee tec age aca gee tac atg caa etc age age etg 336
Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gin Leu Ser Ser Leu
100 105 110

aca tct gag gae tct gcg gtc tac ttc tgt gca aga gcg agg aaa act 3 84

Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Ala Arg Lys Thr
115 120 125

tee tgg ttt get tac tgg ggc caa ggg act etg gtc act gtc tct gcg 432
Ser Trp Phe Ala Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ala
130 135 140

<210> 159

<211> 144

<212> PRT

<213> Mus musculus

<400> 159

Met Val Leu Ala Ser Ser Thr Thr Ser lie His Thr Met Leu Leu Leu
15 10 15

Leu Leu Met Leu Ala Gin Pro Ala Met Ala Gin Val Gin Leu Gin Gin
20 25 30

Ser Gly Pro Glu Leu Val Lys Pro Gly Ala Ser Val Lys He Ser Cys
35 40 45

Lys Ala Ser Gly Tyr Ala Phe Ser Ser Ser Trp Met Asn Trp Met Lys
50 55 60

Gin Arg Pro Gly Lys Gly Leu Glu Trp He Gly Arg He Tyr Pro Gly
65 70 75 80

Asp Gly Asp Thr Asn Tyr Asn Gly Lys Phe Lys Gly Lys Ala Thr Leu
85 90 95

59

Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr Met Gin Leu Ser Ser Leu
100 105 110

Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg Ala Arg Lys Thr
115 120 125

Ser Trp Phe Ala Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ala
130 135 140

<210> 160

<211> 345

<212> DNA

<213> Mus musculus

<220>

<221> CDS

<222> (1) . . (345)

<400> 160

gac att gtg ttg aca cag tct caa aaa ttc atg tec aca tea gta gga 48

Asp lie Val Leu Thr Gin Ser Gin Lys Phe Met Ser Thr Ser Val Gly
15 10 15

gac agg gtc age ate age tge aag gee agt cag aat gtg ggt aat att 96
Asp Arg Val Ser lie Ser Cys Lys Ala Ser Gin Asn Val Gly Asn lie
20 25 30

ata gee tgg tat caa cag aaa eca ggg caa tct cet aaa gca etg att 144
lie Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ser Pro Lys Ala Leu lie
35 40 45

tac ttg gca tee tac egg tac agt gga gtc cet gat cgc ttc aca ggc 192
Tyr Leu Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60

agt gga tct ggg aca gat ttc act etc acc att agt aat gtg cag tct 240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr He Ser Asn Val Gin Ser
65 70 75 80

gaa gac ttg gca gag tat ttc tgt cag caa tat age age tct ccg etc 288
Glu Asp Leu Ala Glu Tyr Phe Cys Gin Gin Tyr Ser Ser Ser Pro Leu
85 90 95

acg ttc ggt get ggg acc aag etg gaa ata aag gac tac aag gat gac 336
Thr Phe Gly Ala Gly Thr Lys Leu Glu He Lys Asp Tyr Lys Asp Asp
100 105 110

gac gat aag
Asp Asp Lys
115

345

60

<210> 161

<211> 115

<212> PRT

<213> Mus musculus

<400> 161

Asp lie Val Leu Thr Gin Ser Gin Lys Phe Met Ser Thr Ser Val Gly
15 10 15

Asp Arg Val Ser lie Ser Cys Lys Ala Ser Gin Asn Val Gly Asn lie
20 25 30

lie Ala Trp Tyr Gin Gin Lys Pro Gly Gin Ser Pro Lys Ala Leu lie
35 40 45

Tyr Leu Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly
50 55 60

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr lie Ser Asn Val Gin Ser
65 70 75 80

Glu Asp Leu Ala Glu Tyr Phe Cys Gin Gin Tyr Ser Ser Ser Pro Leu
85 90 95

Thr Phe Gly Ala Gly Thr Lys Leu Glu lie Lys Asp Tyr Lys Asp Asp
100 105 110

Asp Asp Lys

115

<210>

162

<211>

116

<212>

PRT

<213>

Mus musculus

<400>

162

Asp Val

Gin Leu Gin

1

5

Ser Leu

Ser Leu Thr

20

10 15

25 30

Tyr Ala Trp Ser Trp lie Arg Gin Leu Pro Gly Asn Lys Leu Glu Trp
35 40 45

61

Met Gly Tyr He Thr Tyr Ser Gly Tyr Ser He Tyr Asn Pro Ser Leu
50 55 60

Lys Ser Arg He Ser He Ser Arg Asp Thr Ser Lys Asn Gin Leu Phe
65 70 75 80

Leu Gin Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys
85 90 95

Val Gly Gly Tyr Asp Asn Met Asp Tyr Trp Gly Gin Gly Thr Ser Val
100 105 110

Thr Val Ser Ser

115

<210>

163

<211>

108

<212>

PRT

<213>

Mus musculus

<400>

163

Gin He Val Leu Thr Gin Ser Pro Ala He Met Ser Ala Ser Pro Gly
15 10 15

Glu Lys Val Thr Leu Thr Cys Ser Ala Ser Ser Ser Val Ser Ser Ser
20 25 30

His Leu Tyr Trp Tyr Gin Gin Lys Pro Gly Ser Ser Pro Lys Leu Trp
35 40 45

He Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser
50 55 60

Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr He Ser Asn Met Glu
65 70 75 80

Thr Glu Asp Ala Ala Ser Tyr Phe Cys His Gin Trp Ser Ser Tyr Pro
85 90 95

Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu He Lys
100 105

<210>

164

62

<211> 1924

<212> DNA

<213> Macaca fascicularis
<220>

<221> CDS

<222> (11) . . (1918)

<400> 164

gaattccacc atg ccc tec tgg gcc etc ttc atg gtc acc tec tgc etc 49

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu
15 10

etc ctg gee ect caa aac ctg gcc caa gtc age age caa gat gtc tee 97
Leu Leu Ala Pro Gin Asn Leu Ala Gin Val Ser Ser Gin Asp Val Ser
15 20 25

ttg ctg gcc teg gac tea gag ccc ctg aag tgt ttc tec cga aca ttt 145
Leu Leu Ala Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe
30 35 40 45

gag gac etc act tgc ttc tgg gat gag gaa gag gca gca ccc agt ggg 193
Glu Asp Leu Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly
50 55 60

aca tac cag ctg ctg tat gee tac ccg ggg gag aag ccc cgt gcc tgc 241
Thr Tyr Gin Leu Leu Tyr Ala Tyr Pro Gly Glu Lys Pro Arg Ala Cys
65 70 75

ccc ctg agt tct cag age gtg ccc cgc ttt gga ace cga tac gtg tgc 289
Pro Leu Ser Ser Gin Ser Val Pro Arg Phe Gly Thr Arg Tyr Val Cys
80 85 90

cag ttt cca gcc cag gaa gaa gtg cgt etc ttc tct ccg ctg eac etc 337
Gin Phe Pro Ala Gin Glu Glu Val Arg Leu Phe Ser Pro Leu His Leu
95 100 105

tgg gtg aag aat gtg ttc eta aac cag act cag att cag cga gtc etc 385
Trp Val Lys Asn Val Phe Leu Asn Gin Thr Gin lie Gin Arg Val Leu
110 115 120 125

ttt gtg gac agt gta ggc ctg ccg get ccc ccc agt ate ate aag gee 433
Phe Val Asp Ser Val Gly Leu Pro Ala Pro Pro Ser lie lie Lys Ala
130 135 140

atg ggt ggg age cag cca ggg gaa ctt cag ate age tgg gag gee cca 481
Met Gly Gly Ser Gin Pro Gly Glu Leu Gin lie Ser Trp Glu Ala Pro
145 150 155

get cca gaa ate agt gat ttc ctg agg tac gaa etc cgc tat ggc ccc 529
Ala Pro Glu lie Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro
160 165 170

aaa gat etc aag aac tec act ggt ccc acg gtc ata cag ttg ate gcc 577
Lys Asp Leu Lys Asn Ser Thr Gly Pro Thr Val lie Gin Leu lie Ala
175 180 185

63

aca gaa acc
Thr Glu Thr
190

ctg gac cag
Leu Asp Gin

cca aag cag
Pro Lys Gin

ggt gga age
Gly Gly Ser
240

ctg cag ctg
Leu Gin Leu
255

gga tec tgg
Gly Ser Trp
270

gca att gga
Ala He Gly

caa tgg cag
Gin Trp Gin

age agg gca
Ser Arg Ala
320

tgt gaa gag
Cys Glu Glu
335

tct cgc tge
Ser Arg Cys
350

gtg gag gtg
Val Glu Val

cct ttc tgg
Pro Phe Trp

tgg agg gag
Trp Arg Glu
400

tea tee tgg

tge tge cct
Cys Cys Pro
195

tct cca tgt
Ser Pro Cys
210

ace tec cca
Thr Ser Pro
225

tge etc ate
Cys Leu He

cgc age gaa
Arg Ser Glu

tee etc cct
Ser Leu Pro
275

ctg caa tge
Leu Gin Cys
290

caa gag gac
Gin Glu Asp
305

egg tge tge
Arg Cys Cys

gaa gag aaa
Glu Glu Lys

eac ttc aag
His Phe Lys
355

aec aca gee
Thr Thr Ala
370

ate cac cag
He His Gin
385

ate tee age
He Ser Ser

gca gee eaa

get ctg cag
Ala Leu Gin

get cag ccc
Ala Gin Pro

act aga gaa
Thr Arg Glu
230

tea gga etc
Ser Gly Leu
245

cct gat ggg
Pro Asp Gly
260

gtg act gtg
Val Thr Val

ttt acc ttg
Phe Thr Leu

cat get agt
His Ala Ser
310

ccc aga gac
Pro Arg Asp
325

aca aat cca
Thr Asn Pro
340

tea ega aat
Ser Arg Asn

ctg ggt get
Leu Gly Ala

get gtg cgc
Ala Val Arg
390

ggg cat ctg
Gly His Leu
405

gag aec tge

agg cca cac
Arg Pro His
200

aca atg cee
Thr Met Pro
215

get tea get
Ala Ser Ala

cag cct gge
Gin Pro Gly

ate tee etc
He Ser Leu
265

gac ctg cct
Asp Leu Pro
280

gac ctg aag
Asp Leu Lys
295

tec caa ggt
Ser Gin Gly

agg tac ccc
Arg Tyr Pro

gga tta cag
Gly Leu Gin
345

gac age gtt
Asp Ser Val
360

gtt cac agt
Val His Ser
375

etc ccc ace
Leu Pro Thr

gaa ttg gag
Glu Leu Glu

tat caa etc

tea gee tct
Ser Ala Ser

tgg caa gat
Trp Gin Asp
220

Ctg aca gca
Leu Thr Ala
235

aac tec tac
Asn Ser Tyr
250

ggt gge tec
Gly Gly Ser

gga gat gca
Gly Asp Ala

aat gtt ace
Asn Val Thr
300

ttc ttc tac
Phe Phe Tyr
315

ate tgg gag
He Trp Glu
330

ace cca cag
Thr Pro Gin

att cac ate
He His He

tac ctg gge
Tyr Leu Gly
380

cca aac ttg
Pro Asn Leu
395

tgg cag eac
Trp Gin His
410

cga tac aca

get 625

Ala

205

gga 673
Gly

gtg 721
Val

tgg 769
Trp

tgg 817
Trp

gtg 865

Val

285

tgt 913
Cys

cac 961
His

gac 1009
Asp

ttc 1057
Phe

ett 1105

Leu

365

tec 1153
Ser

eac 1201
His

cca 1249
Pro

gga 12 97

64

Ser Ser Trp
415

gaa ggc cat
Glu Gly His
430

gga ggg acc
Gly Gly Thr

cgc gcc agg
Arg Ala Arg

teg gac cca
Ser Asp Pro
480

ttg gtg acc
Leu Val Thr
495

ctg ctg ctg
Leu Leu Leu
510

cat gcc ctg
His Ala Leu

tac ctt agg
Tyr Leu Arg

gat acc tgt
Asp Thr Cys
560

tec tea gag
Ser Ser Glu
575

gac tac cga
Asp Tyr Arg
590

gtg tge cca
Val Cys Pro

gee aae cat
Ala Asn His

gtegae

Ala Ala Gin

eag gac tgg
Gin Asp Trp
435

ctg gag ctg
Leu Glu Leu
450

etc aat ggc
Leu Asn Gly
465

get agg gtg
Ala Arg Val

get ctg ctg
Ala Leu Leu

ctg agg tgg
Leu Arg Trp
515

tgg eee tea
Trp Pro Ser
530

gac act gea
Asp Thr Ala
545

gaa gaa gtg
Glu Glu Val

agg act ect
Arg Thr Pro

aga ttg eag
Arg Leu Gin
595

cec atg get
Pro Met Ala
610

tec tac eta
Ser Tyr Leu
625

Glu Thr Cys
420

aag gtg ctg
Lys Val Leu

cgc ccg cga
Arg Pro Arg

cec ace tac
Pro Thr Tyr
470

gag ace gcc
Glu Thr Ala
485

eta gtg ctg
Leu Val Leu
500

cag ttt ect
Gin Phe Pro

ctt cca gat
Leu Pro Asp

gee ctg agt
Ala Leu Ser
550

gaa eee age
Glu Pro Ser
565

ttg cec ctg
Leu Pro Leu
580

ect tet tgc
Pro Ser Cys

gag tea ggg
Glu Ser Gly

cca eta age
Pro Leu Ser
630

Tyr Gin Leu
425

gag ccg ect
Glu Pro Pro
440

tet cgc tac
Ser Arg Tyr
455

caa ggt cec
Gin Gly Pro

acc gag acc
Thr Glu Thr

ggc etc age
Gly Leu Ser
505

gea cac tac
Ala His Tyr
520

Ctg cac cga
Leu His Arg
535

ccg cec aag
Pro Pro Lys

etc ctt gaa
Leu Leu Glu

tgt tec tec
Cys Ser Ser
585

ctg ggg acc
Leu Gly Thr
600

tee tgc tgt
Ser Cys Cys
615

tat tgg cag
Tyr Trp Gin

Arg Tyr Thr

etc ggg gcc
Leu Gly Ala

egt tta eag
Arg Leu Gin
460

tgg age teg
Trp Ser Ser
475

gee tgg att
Ala Trp lie
490

gcc gtc ctg
Ala Val Leu

agg aga ctg
Arg Arg Leu

gtc eta ggc
Val Leu Gly
540

gee aca gtc
Ala Thr Val
555

ate etc cec
lie Leu Pro
570

cag tee cag
Gin Ser Gin

atg eee ctg
Met Pro Leu

acc ace cac
Thr Thr His
620

eag ect tga
Gin Pro
635

Gly

cga 1345

Arg

445

ctg 1393
Leu

tgg 1441
Trp

tec 1489
Ser

ggc 1537
Gly

agg 1585

Arg

525

eag 1633
Gin

tea 1681
Ser

aag 1729
Lys

atg 1777
Met

tet 1825

Ser

605

att 1873
He

1918

1924

65

<210> 165
<211> 635
<212> PRT

<213> Macaca fascicularis
<400> 165

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala
15 10 15

Pro Gin Asn Leu Ala Gin Val Ser Ser Gin Asp Val Ser Leu Leu Ala
20 25 30

Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu
35 40 45

Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gin
50 55 60

Leu Leu Tyr Ala Tyr Pro Gly Glu Lys Pro Arg Ala Cys Pro Leu Ser
65 70 75 80

Ser Gin Ser Val Pro Arg Phe Gly Thr Arg Tyr Val Cys Gin Phe Pro
85 90 95

Ala Gin Glu Glu Val Arg Leu Phe Ser Pro Leu His Leu Trp Val Lys
100 105 110

Asn Val Phe Leu Asn Gin Thr Gin lie Gin Arg Val Leu Phe Val Asp
115 120 125

Ser Val Gly Leu Pro Ala Pro Pro Ser lie lie Lys Ala Met Gly Gly
130 135 140

Ser Gin Pro Gly Glu Leu Gin lie Ser Trp Glu Ala Pro Ala Pro Glu
145 150 155 160

lie Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Lys Asp Leu
165 170 175

Lys Asn Ser Thr Gly Pro Thr Val lie Gin Leu lie Ala Thr Glu Thr
180 185 190

66

Cys Cys Pro Ala Leu Gin Arg Pro His Ser Ala Ser Ala Leu Asp Gin
195 200 205

Ser Pro Cys Ala Gin Pro Thr Met Pro Trp Gin Asp Gly Pro Lys Gin
210 215 220

Thr Ser Pro Thr Arg Glu Ala Ser Ala Leu Thr Ala Val Gly Gly Ser
225 230 235 240

Cys Leu lie Ser Gly Leu Gin Pro Gly Asn Ser Tyr Trp Leu Gin Leu
245 250 255

Arg Ser Glu Pro Asp Gly lie Ser Leu Gly Gly Ser Trp Gly Ser Trp
260 265 270

Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala lie Gly
275 280 285

Leu Gin Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gin Trp Gin
290 295 300

Gin Glu Asp His Ala Ser Ser Gin Gly Phe Phe Tyr His Ser Arg Ala
305 310 315 320

Arg Cys Cys Pro Arg Asp Arg Tyr Pro lie Trp Glu Asp Cys Glu Glu
325 330 335

Glu Glu Lys Thr Asn Pro Gly Leu Gin Thr Pro Gin Phe Ser Arg Cys
340 345 350

His Phe Lys Ser Arg Asn Asp Ser Val lie His lie Leu Val Glu Val
355 360 365

Thr Thr Ala Leu Gly Ala Val His Ser Tyr Leu Gly Ser Pro Phe Trp
370 375 380

lie His Gin Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu
385 • 390 395 400

lie Ser Ser Gly His Leu Glu Leu Glu Trp Gin His Pro Ser Ser Trp
405 410 415

Ala Ala Gin Glu Thr Cys Tyr Gin Leu Arg Tyr Thr Gly Glu Gly His

67

420 425 430

Gin Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr
435 440 445

Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gin Leu Arg Ala Arg
450 455 460

Leu Asn Gly Pro Thr Tyr Gin Gly Pro Trp Ser Ser Trp Ser Asp Pro
465 470 475 480

Ala Arg Val Glu Thr Ala Thr Glu Thr Ala Trp lie Ser Leu Val Thr
485 490 495

Ala Leu Leu Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu
500 505 510

Leu Arg Trp Gin Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu
515 520 525

Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gin Tyr Leu Arg
530 535 540

Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys
545 550 555 560

Glu Glu Val Glu Pro Ser Leu Leu Glu lie Leu Pro Lys Ser Ser Glu
565 570 575

Arg Thr Pro Leu Pro Leu Cys Ser Ser Gin Ser Gin Met Asp Tyr Arg
580 585 590

Arg Leu Gin Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro
595 600 605

Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His He Ala Asn His
610 615 620

Ser Tyr Leu Pro Leu Ser Tyr Trp Gin Gin Pro
625 630 635

<210> 166

68

<211> 24

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized sequence

<400> 166

caggggccag tggatagact gatg 24

<210> 167

<211> 23

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized sequence

<400> 167

gctcactgga tggtgggaag atg 23

<210> 168

<211> 30

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 168

tagaattcca ccatggaatg gcctttgatc 3 0

<210> 169

<211> 56

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence
<400> 169

agcctgagtc atcacaatat ccgatccgcc tccacctgca gagacagtga ccagag 56

<210> 170

<211> 56

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence
<400> 170

actctggtca ctgtctctgc aggtggaggc ggatcggata ttgtgatgac tcaggc 56

69

<210> 171

<211> 60

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 171

attgcggccg cttatcactt atcgtcgtca tccttgtagt cttttatttc cagcttggtc

<210> 172

<211> 8

<212> PRT

<213> Artificial

<220>

<223> an artificially synthesized FLAG tag sequence

<400> 172

Asp Tyr Lys Asp Asp Asp Asp Lys
1 5

<210> 173

<211> 85

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence
<400> 173

tagaattcca ccatggaatg gcctttgatc tttctcttcc tcctgtcagg aactgcaggt
gtccactccc aggttcagct gcagc

<210> 174

<211> 82

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence
<400> 174

tggtcactgt ctctgcaggt ggtggtggtt cgggtggtgg tggttcgggt ggtggcggat
cggatattgt gatgactcag gc

<210> 175

70

<211> 82

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence
<400> 175

tgagtcatca caatatccga tccgccacca cccgaaccac caccacccga accaccacca 60
cctgcagaga cagtgaccag ag 82

<210> 176

<211> 25

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 176

caggttcagc tgcagcagtc tggac 25

<210> 177

<211> 81

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence
<400> 177

gctgcagctg aacctgcgat ccaccgcctc ccgaaccacc accacccgat ccaccacctc 60
cttttatttc cagcttggtc c 81

<210>

178

<211>

38

<212>

DNA

<213>

Artificial

<220>

<223>

an artificially

<400>

178

gcccagccgg ccatggcgga kgtrmagctt caggagtc 3 8

<210> 179

<211> 38

<212> DNA

<213> Artificial

<220>

71

<223> an artificially synthesized primer sequence

<400> 179

gcccagccgg ccatggcgga ggtbcagctb cagcagtc

<210> 180

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 180

gcccagccgg ccatggcgca ggtgcagctg aagsastc

<210> 181

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 181

gcccagccgg ccatggcgga ggtccarctg caacartc

<210> 182

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 182

gcccagccgg ccatggcgca ggtycagctb cagcartc

<210> 183

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 183

gcccagccgg ccatggcgca ggtycarctg cagcagtc

<210> 184
<211> 38
<212> DNA

72

<213>

Artificial

<220>
<223>

an artificially synthesized primer sequence

<400> 184

gcccagccgg ccatggcgca ggtccacgtg aagcagtc

38

<210> 185

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 185

gcccagccgg ccatggcgga ggtgaasstg gtggaatc 3 8

<210> 186

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 186

gcccagccgg ccatggcgga vgtgawgytg gtggagtc 38

<210> 187

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 187

gcccagccgg ccatggcgga ggtgcagskg gtggagtc 38

<210> 188

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 188

gcccagccgg ccatggcgga kgtgcamctg gtggagtc

38

73

<210> 189

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 189

gcccagccgg ccatggcgga ggtgaagctg atggartc

<210> 190

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 190

gcccagccgg ccatggcgga ggtgcarctt gttgagtc

<210> 191

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 191

gcccagccgg ccatggcgga rgtraagctt ctcgagtc

<210> 192

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 192

gcccagccgg ccatggcgga agtgaarstt gaggagtc

<210> 193

<211> 40

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 193

74

gcccagccgg ccatggcgca ggttactctr aaagwgtstg

<210> 194

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 194

gcccagccgg ccatggcgca ggtccaactv cagcarcc

<210> 195

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 195

gcccagccgg ccatggcgga tgtgaacttg gaagtgtc

<210> 196

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 196

gcccagccgg ccatggcgga ggtgaaggtc atcgagtc

<210> 197

<211> 36

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 197

ggagccgccg ccgcccgagg aaacggtgac cgtggt

<210> 198

<211> 36

<212> DNA

<213> Artificial

75

<223> an artificially synthesized primer sequence

<400> 198

ggagccgccg ccgcccgagg agactgtgag agtggt

<210> 199

<211> 36

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 199

ggagccgccg ccgcccgcag agacagtgac cagagt

<210> 200

<211> 36

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 200

ggagccgccg ccgcccgagg agacggtgac tgaggt

<210> 201

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 201

ggcggcggcg gctccgayat ccagctgact cagcc

<210> 202

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 202

ggcggcggcg gctccgayat tgttctcwcc cagtc

<210> 203

<211> 35

<212> DNA

76

<213>

Artificial

<220>
<223>

an artificially synthesized primer sequence

<400> 203

ggcggcggcg gctccgayat tgtgmtmact cagtc

35

<210> 204

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 204

ggcggcggcg gctccgayat tgtgytraca cagtc 3 5

<210> 205

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 205

ggcggcggcg gctccgayat tgtratgacm cagtc 3 5

<210> 206

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 206

ggcggcggcg gctccgayat tmagatramc cagtc 35

<210> 207

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 207

ggcggcggcg gctccgayat tcagatgayd cagtc

35

77

<210> 208

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 208

ggcggcggcg gctccgayat ycagatgaca cagac

<210> 209

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 209

ggcggcggcg gctccgayat tgttctcawc cagtc

<210> 210

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 210

ggcggcggcg gctccgayat tgwgctsacc caatc

<210> 211

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 211

ggcggcggcg gctccgayat tstratgacc carte

<210> 212

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 212

78

ggcggcggcg gctccgayrt tktgatgacc carac

<210> 213

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 213

ggcggcggcg gctccgayat tgtgatgacb cagkc

<210> 214

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 214

ggcggcggcg gctccgayat tgtgataacy cagga

<210> 215

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 215

ggcggcggcg gctccgayat tgtgatgacc cagwt

<210> 216

<211> 35

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 216

ggcggcggcg gctccgayat tgtgatgaca caacc

<210> 217

<211> 35

<212> DNA

<213> Artificial

<220>

79

<223> an artificially synthesized primer sequence

<400> 217

ggcggcggcg gctccgayat tttgctgact cagtc

<210> 218

<211> 38

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 218

ggcggcggcg gctccgatgc tgttgtgact caggaatc

<210> 219

<211> 36

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 219

ggaattcggc ccccgaggcc ttgatttcca gcttgg

<210> 220

<211> 36

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 220

ggaattcggc ccccgaggcc tttatttcca gcttgg

<210> 221

<211> 36

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 221

ggaattcggc ccccgaggcc tttatttcca actttg

<210> 222

<211> 36

<212> DNA

80

<213>

Artificial

<220>
<223>

an artificially synthesized primer sequence

<400> 222

ggaattcggc ccccgaggcc ttcagctcca gcttgg

36

<210> 223

<211> 39

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized primer sequence

<400> 223

ggaattcggc ccccgaggcc cctaggacag tcagtttgg 3 9

<210> 224

<211> 27

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized sequence

<400> 224

ttactcgcgg cccagccggc catggcg 27

<210> 225

<211> 17

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized sequence

<400> 225

ggaattcggc ccccgag 17

<210> 226

<211> 20

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized sequence

<400> 226

tcacttacag gctctctact

20

81

<210> 227

<211> 20

<212> DNA

<213> Artificial

<220>

<223> an artificially synthesized sequence

<400> 227

caggtggggt ctttcattcc 2 0

<210> 228

<211> 354

<212> DNA

<213> Homo sapiens

<400> 228

caggtgcagc tggtgcagtc tggacctgag gtgaagaagc ctggggcctc agtgaaggtc 60

tcctgcaagg cttctggata caccttcacc aactcctgga tgaactgggt gaggcagagg 120

cctggaaagg gtcttgagtg gatgggacgg atttatcctg gagatggaga aactatctac 180

aatgggaaat tcagggtcag agtcacgatt accgcggacg aatccacgag cacagcctac 240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctat 3 00

gatgattact cgtttgctta ctggggccag ggaaccacgg tcaccgtctc ttca 354

<210> 229

<211> 118

<212> PRT

<213> Homo sapiens

<400> 229

Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
15 10 15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser
20 25 30

Trp Met Asn Trp Val Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp Met
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe
50 55 60

Arg Val Arg Val Thr He Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80

82

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95

Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Thr Val Thr Val Ser Ser

115

<210>

230

<211>

30

<212>

PRT

<213>

Homo

<400>

230

sapiens

Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
15 10 15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
20 25 30

<210> 231

<211> 5

<212> PRT

<213> Homo sapiens

<400> 231

Asn Ser Trp Met Asn
1 5

<210>

232

<211>

14

<212>

PRT

<213>

Homo

<400>

232

sapiens

Trp Val Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp Met Gly
15 10

<210>

233

<211>

17

<212>

PRT

<213>

Homo

<400>

233

sapiens

83

Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe Arg
15 10 15

Val

<210> 234

<211> 32

<212> PRT

<213> Homo sapiens

<400> 234

Arg Val Thr He Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu
15 10 15

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
20 25 30

<210>

235

<211>

9

<212>

PRT

<213>

Homo

<400>

235

Gly Tyr Asp

1

<210>

236

<211>

11

<212>

PRT

<213>

Homo

<400>

236

Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser
15 10

<210>

237

<211>

336

<212>

DNA

<213>

Homo sapiens

<400>

237

gatattgtga tgactcagtc tgcactctcc ctgcccgtca cccctggaga gccggcctcc 60
atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg 120
ttccagcaga agccagggca gtctccacag ctcctgatct atcggatgtc caaccttgcc 180

84

tcaggggtcc ctgacaggtt cagtggcagt ggatcaggca cagcttttac actgaaaatc 240
agcagagtgg aggctgagga tgttggggtt tattactgca tgcaacatat agaatatcct 300
tttacgttcg gccaagggac caaactggaa atcaaa 336

<210> 238

<211> 112

<212> PRT

<213> Homo sapiens

<400> 238

Asp lie Val Met Thr Gin Ser Ala Leu Ser Leu Pro Val Thr Pro Gly
15 10 15

Glu Pro Ala Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Gin Gin Lys Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu He Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys He
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

He Glu Tyr Pro Phe Thr Phe Gly Gin Gly Thr Lys Leu Glu He Lys
100 105 110

<210>

239

<211>

23

<212>

PRT

<213>

Homo

<400>

239

Asp He Val Met Thr Gin Ser Ala Leu Ser Leu Pro Val Thr Pro Gly
15 10 15

Glu Pro Ala Ser He Ser Cys
20

85

<210> 240

<211> 16

<212> PRT

<213> Homo sapiens

<400> 240

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 241

<211> 15

<212> PRT

<213> Homo sapiens

<400> 241

Trp Phe Gin Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu lie Tyr
15 10 15

<210> 242

<211> 7

<212> PRT

<213> Homo sapiens

<400> 242

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 243

<211> 32

<212> PRT

<213> Homo sapiens

<400> 243

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr
15 10 15

Leu Lys lie Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
20 25 30

<210> 244

<211> 9

<212> PRT

<213> Homo sapiens

<400> 244

Met Gin His He Glu Tyr Pro Phe Thr
1 5

86

<210> 245

<211> 10

<212> PRT

<213> Homo sapiens

<400> 245

Phe Gly Gin Gly Thr Lys Leu Glu lie Lys

<210> 246

<211> 1924

<212> DNA

<213> Homo sapiens

<400> 246

gaattccacc atgccctcct gggccctctt catggtcacc tcctgcctcc tcctggcccc 60

tcaaaacctg gcccaagtca gcagccaaga tgtctccttg ctggcatcag actcagagcc 120

cctgaagtgt ttctcccgaa catttgagga cctcacttgc ttctgggatg aggaagaggc 180

agcgcccagt gggacatacc agctgctgta tgcctacccg cgggagaagc cccgtgcttg 24 0

ccccctgagt tcccagagca tgccccactt tggaacccga tacgtgtgcc agtttccaga 300

ccaggaggaa gtgcgtctct tctttccgct gcacctctgg gtgaagaatg tgttcctaaa 360

ccagactcgg actcagcgag tcctctttgt ggacagtgta ggcctgccgg ctccccccag 420

tatcatcaag gccatgggtg ggagccagcc aggggaactt cagatcagct gggaggagcc 480

agctccagaa atcagtgatt tcctgaggta cgaactccgc tatggcccca gagatcccaa 540

gaactccact ggtcccacgg tcatacagct gattgccaca gaaacctgct gccctgctct 600

gcagagacct cactcagcct ctgctctgga ccagtctcca tgtgctcagc ccacaatgcc 660

ctggcaagat ggaccaaagc agacctcccc aagtagagaa gcttcagctc tgacagcaga 72 0

gggtggaagc tgcctcatct caggactcca gcctggcaac tcctactggc tgcagctgcg 780

cagcgaacct gatgggatct ccctcggtgg ctcctgggga tcctggtccc tccctgtgac 840

tgtggacctg cctggagatg cagtggcact tggactgcaa tgctttacct tggacctgaa 900

gaatgttacc tgtcaatggc agcaacagga ccatgctagc tcccaaggct tcttctacca 960

cagcagggca cggtgctgcc ccagagacag gtaccccatc tgggagaact gcgaagagga 102 0

agagaaaaca aatccaggac tacagacccc acagttctct cgctgccact tcaagtcacg 1080

aaatgacagc attattcaca tccttgtgga ggtgaccaca gccccgggta ctgttcacag 1140

87

ctacctgggc

tcccctttct

ggatccacca

ggctgtgcgc

ctccccaccc

caaacttgca

1200

ctggagggag

atctccagtg

ggcatctgga

attggagtgg

cagcacccat

cgtcctgggc

1260

agcccaagag

acctgttatc

aactccgata

cacaggagaa

ggccatcagg

actggaaggt

1320

gctggagccg

cctctcgggg

cccgaggagg

gaccctggag

ctgcgcccgc

gatctcgcta

1380

ccgtttacag

ctgcgcgcca

ggctcaacgg

ccccacctac

caaggtccct

ggagctcgtg

1440

gtcggaccca

actagggtgg

agaccgccac

cgagaccgcc

tggatctcct

tggtgaccgc

1500

tctgcatcta

gtgctgggcc

tcagcgccgt

cctgggcctg

ctgctgctga

ggtggcagtt

1560

tcctgcacac

tacaggagac

tgaggcatgc

cctgtggccc

tcacttccag

acctgcaccg

1620

ggtcctaggc

cagtacctta

gggacactgc

agccctgagc

ccgcccaagg

ccacagtctc

1680

agatacctgt

gaagaagtgg

aacccagcct

ccttgaaatc

ctccccaagt

cctcagagag

1740

gactcctttg

cccctgtgtt

cctcccaggc

N— ' V— ' d O ^-J \^

L** CL ^-j d CL W

1" dps CTPP t~ t" C

1800

ttgcctgggg

accatgcccc

tgtctgtgtg

cccacccatg

gctgagtcag

ggtcctgctg

1860

taccacccac

attgccaacc

attcctacct

accactaagc

tattggcagc

agccttgagt

1920

cgac

1924

<210> 247

<211> 1924

<212> DNA

<213> Homo sapiens

<220> .

<221> CDS

<222> (11) . . (1918)

<400> 247

gaattccacc atg ccc tec tgg gcc etc ttc atg gtc acc tec tgc etc 49
Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu
15 10

etc etg gee cet caa aac ctg gee caa gtc age age caa gat gtc tee 97
Leu Leu Ala Pro Gin Asn Leu Ala Gin Val Ser Ser Gin Asp Val Ser
15 20 25

ttg etg gea tea gae tea gag ccc ctg aag tgt ttc tec cga aea ttt 145
Leu Leu Ala Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe
30 35 40 45

gag gac etc act tge ttc tgg gat gag gaa gag gea geg ccc agt ggg 193
Glu Asp Leu Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly
50 55 60

aea tae eag ctg etg tat gee tac eeg egg gag aag ccc cgt get tge 241
Thr Tyr Gin Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys

88

65 70 75

ccc ctg agt tec cag age atg ccc cac ttt gga acc cga tac gtg tgc 289
Pro Leu Ser Ser Gin Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys
80 85 90

cag ttt cca gac cag gag gaa gtg cct etc ttc ttt ccg ctg cac etc 337
Gin Phe Pro Asp Gin Glu Glu Val Pro Leu Phe Phe Pro Leu His Leu
95 100 105

tgg gtg aag aat gtg ttc eta aac cag act egg act cag cga gtc etc 385
Trp Val Lys Asn Val Phe Leu Asn Gin Thr Arg Thr Gin Arg Val Leu
110 115 120 125

ttt gtg gac agt gta ggc ctg ccg get ccc ccc agt ate ate aag gee 433
Phe Val Asp Ser Val Gly Leu Pro Ala Pro Pro Ser lie lie Lys Ala
130 135 140

atg ggt ggg age cag cca ggg gaa ctt eag ate age tgg gag gag cca 481
Met Gly Gly Ser Gin Pro Gly Glu Leu Gin lie Ser Trp Glu Glu Pro
145 150 155

get cca gaa ate agt gat ttc ctg agg tac gaa etc cgc tat ggc ccc 52 9

Ala Pro Glu lie Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro
160 165 170

aga gat ccc aag aac tec act ggt ccc acg gte ata cag ctg att gee 577
Arg Asp Pro Lys Asn Ser Thr Gly Pro Thr Val lie Gin Leu lie Ala
175 180 185

aca gaa ace tgc tgc ect get ctg eag aga cct cac tea gee tet get 625
Thr Glu Thr Cys Cys Pro Ala Leu Gin Arg Pro His Ser Ala Ser Ala
190 195 200 205

Ctg gac cag tet cca tgt get cag ccc aca atg ccc tgg caa gat gga 673
Leu Asp Gin Ser Pro Cys Ala Gin Pro Thr Met Pro Trp Gin Asp Gly
210 215 220

cca aag eag acc tee cca agt aga gaa get tea get ctg aea gca gag 721
Pro Lys Gin Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu
225 230 235

ggt gga age tgc etc ate tea gga etc cag cct ggc aac tec tac tgg 769
Gly Gly Ser Cys Leu lie Ser Gly Leu Gin Pro Gly Asn Ser Tyr Trp
240 245 250

Ctg cag ctg cgc age gaa cct gat ggg ate tee etc ggt ggc tee tgg 817
Leu Gin Leu Arg Ser Glu Pro Asp Gly lie Ser Leu Gly Gly Ser Trp
255 260 265

gga tec tgg tec etc cct gtg act gtg gac ctg cct gga gat gca gtg 865
Gly Ser Trp Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val
270 275 280 285

gca ctt gga ctg caa tgc ttt ace ttg gac ctg aag aat gtt ace tgt 913
Ala Leu Gly Leu Gin Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys
290 295 300

89

caa tgg cag
Gin Trp Gin

age agg gca
Ser Arg Ala
320

tgc gaa gag
Cys Glu Glu
335

tct cgc tgc
Ser Arg Cys
350

gtg gag gtg
Val Glu Val

cct ttc tgg
Pro Phe Trp

tgg agg gag
Trp Arg Glu
400

teg tec tgg
Ser Ser Trp
415

gaa gge cat
Glu Gly His
430

gga ggg acc
Gly Gly Thr

cgc gee agg
Arg Ala Arg

teg gae eca
Ser Asp Pro
480

ttg gtg acc
Leu Val Thr
495

ctg ctg ctg
Leu Leu Leu
510

caa cag gac
Gin Gin Asp
305

egg tgc tgc
Arg Cys Cys

gaa gag aaa
Glu Glu Lys

cac ttc aag
His Phe Lys
355

acc aca gee
Thr Thr Ala
370

ate cac cag
He His Gin
385

ate tec agt
He Ser Ser

gca gee caa
Ala Ala Gin

cag gae tgg
Gin Asp Trp
435

ctg gag ctg
Leu Glu Leu
450

etc aac gge
Leu Asn Gly
465

act agg gtg
Thr Arg Val

get ctg eat
Ala Leu His

ctg agg tgg
Leu Arg Trp
515

cat get age
His Ala Ser
310

ecc aga gac
Pro Arg Asp
325

aca aat eca
Thr Asn Pro
340

tea cga aat
Ser Arg Asn

eeg ggt act
Pro Gly Thr

get gtg cgc
Ala Val Arg
390

ggg eat ctg
Gly His Leu
405

gag acc tgt
Glu Thr Cys
420

aag gtg ctg
Lys Val Leu

cgc eeg cga
Arg Pro Arg

cec acc tac
Pro Thr Tyr
470

gag acc gee
Glu Thr Ala
485

eta gtg ctg
Leu Val Leu
500

cag ttt cct
Gin Phe Pro

tec caa gge
Ser Gin Gly

agg tac cec
Arg Tyr Pro

gga eta cag
Gly Leu Gin
345

gac age att
Asp Ser He
360

gtt cac age
Val His Ser
375

etc cec acc
Leu Pro Thr

gaa ttg gag
Glu Leu Glu

tat caa etc
Tyr Gin Leu
425

gag eeg cct
Glu Pro Pro
440

tct cgc tac
Ser Arg Tyr
455

caa ggt cec
Gin Gly Pro

acc gag acc
Thr Glu Thr

gge etc age
Gly Leu Ser
505

gca cac tac
Ala His Tyr
520

ttc ttc tac
Phe Phe Tyr
315

ate tgg gag
He Trp Glu
330

acc eca cag
Thr Pro Gin

att cac ate
He His He

tac ctg gge
Tyr Leu Gly
380

eca aac ttg
Pro Asn Leu
395

tgg cag cac
Trp Gin His
410

cga tac aca
Arg Tyr Thr

etc ggg gee
Leu Gly Ala

cgt tta cag
Arg Leu Gin
460

tgg age teg
Trp Ser Ser
475

gee tgg ate
Ala Trp He
490

gee gtc ctg
Ala Val Leu

agg aga ctg
Arg Arg Leu

cac 961
His

aac 1009
Asn

ttc 1057
Phe

ett 1105

Leu

365

tec 1153
Ser

cac 1201
His

eca 1249
Pro

gga 1297
Gly

cga 1345

Arg

445

Ctg 1393
Leu

tgg 1441
Trp

tee 1489
Ser

gge 1537
Gly

agg 1585

Arg

525

90

cat gcc ctg tgg ccc tea ctt cca gac ctg cac egg gtc eta ggc eag 1633
His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gin
530 535 540

tac ett agg gac act gea gee ctg age ccg ccc aag gcc aca gtc tea 1681
Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser
545 550 555

gat acc tgt gaa gaa gtg gaa ccc age etc ctt gaa ate etc ccc aag 1729
Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu lie Leu Pro Lys
560 565 570

tee tea gag agg act ect ttg ccc ctg tgt tee tec eag gcc cag atg 1777
Ser Ser Glu Arg Thr Pro Leu Pro Leu Cys Ser Ser Gin Ala Gin Met
575 580 585

gac tac cga aga ttg eag cet tct tgc ctg ggg ace atg ccc ctg tet 1825
Asp Tyr Arg Arg Leu Gin Pro Ser Cys Leu Gly Thr Met Pro Leu Ser
590 595 600 605

gtg tgc cca ccc atg get gag tea ggg tee tgc tgt ace ace cac att 1873
Val Cys Pro Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His He
610 615 620

gcc aac eat tec tac eta cca eta age tat tgg eag cag cet tga 1918
Ala Asn His Ser Tyr Leu Pro Leu Ser Tyr Trp Gin Gin Pro
625 630 635

gtcgac 1924

<210> 248

<211> 635

<212> PRT

<213> Homo sapiens

<400> 248

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala
15 10 15

Pro Gin Asn Leu Ala Gin Val Ser Ser Gin Asp Val Ser Leu Leu Ala
20 25 30

Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu
35 40 45

Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gin
50 55 60

Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser
65 70 75 80

91

Ser Gin Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys Gin Phe Pro
85 90 95

Asp Gin Glu Glu Val Pro Leu Phe Phe Pro Leu His Leu Trp Val Lys
100 105 110

Asn Val Phe Leu Asn Gin Thr Arg Thr Gin Arg Val Leu Phe Val Asp
115 120 125

Ser Val Gly Leu Pro Ala Pro Pro Ser lie lie Lys Ala Met Gly Gly
130 135 140

Ser Gin Pro Gly Glu Leu Gin lie Ser Trp Glu Glu Pro Ala Pro Glu
145 150 155 160

lie Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro
165 170 175

Lys Asn Ser Thr Gly Pro Thr Val lie Gin Leu lie Ala Thr Glu Thr
180 185 190

Cys Cys Pro Ala Leu Gin Arg Pro His Ser Ala Ser Ala Leu Asp Gin
195 200 205

Ser Pro Cys Ala Gin Pro Thr Met Pro Trp Gin Asp Gly Pro Lys Gin
210 215 220

Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser
225 230 235 240

Cys Leu lie Ser Gly Leu Gin Pro Gly Asn Ser Tyr Trp Leu Gin Leu
245 250 255

Arg Ser Glu Pro Asp Gly lie Ser Leu Gly Gly Ser Trp Gly Ser Trp
260 265 270

Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala Leu Gly
275 280 285

Leu Gin Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gin Trp Gin
290 295 300

92

Gin Gin Asp His Ala Ser Ser Gin Gly Phe Phe Tyr His Ser Arg Ala
305 310 315 320

Arg Cys Cys Pro Arg Asp Arg Tyr Pro lie Trp Glu Asn Cys Glu Glu
325 330 335

Glu Glu Lys Thr Asn Pro Gly Leu Gin Thr Pro Gin Phe Ser Arg Cys
340 345 350

His Phe Lys Ser Arg Asn Asp Ser lie lie His lie Leu Val Glu Val
355 360 365

Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser Pro Phe Trp
370 375 380

lie His Gin Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu
385 390 395 400

lie Ser Ser Gly His Leu Glu Leu Glu Trp Gin His Pro Ser Ser Trp
405 410 415

Ala Ala Gin Glu Thr Cys Tyr Gin Leu Arg Tyr Thr Gly Glu Gly His
420 425 430

Gin Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr
435 440 445

Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gin Leu Arg Ala Arg
450 455 460

Leu Asn Gly Pro Thr Tyr Gin Gly Pro Trp Ser Ser Trp Ser Asp Pro
465 470 475 480

Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp lie Ser Leu Val Thr
485 490 495

Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu
500 505 510

Leu Arg Trp Gin Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu
515 520 525

Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gin Tyr Leu Arg

93

530 535 540

Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys
545 550 555 560

Glu Glu Val Glu Pro Ser Leu Leu Glu lie Leu Pro Lys Ser Ser Glu
565 570 575

Arg Thr Pro Leu Pro Leu Cys Ser Ser Gin Ala Gin Met Asp Tyr Arg
580 585 590

Arg Leu Gin Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro
595 600 605

Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His lie Ala Asn His
610 615 620

Ser Tyr Leu Pro Leu Ser Tyr Trp Gin Gin Pro
625 630 635

<210> 249

<211> 1924

<212> DNA

<213> Homo sapiens

<220>

<221> CDS

<222> (11) . . (1918)

<400> 249

gaattccacc atg ccc tec tgg gcc etc ttc atg gtc acc tec tgc etc 49
Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu
15 10

etc ctg gcc eet caa aac etg gee eaa gtc age age caa gat gtc tec 97
Leu Leu Ala Pro Gin Asn Leu Ala Gin Val Ser Ser Gin Asp Val Ser
15 20 25

ttg ctg gca tea gae tea gag eee ctg aag tgt ttc tee ega aca ttt 145
Leu Leu Ala Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe
30 35 40 45

gag gae etc act tge ttc tgg gat gag gaa gag gca geg eee agt ggg 193
Glu Asp Leu Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly
50 55 60

aca tac cag ctg etg tat gcc tac ccg egg gag aag ccc egt get tgc 241
Thr Tyr Gin Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys
65 70 75

94

ccc ctg agt tec cag age atg ccc cac ttt gga acc cga tac gtg tgc 289
Pro Leu Ser Ser Gin Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys
80 85 90

cag ttt cca gac cag gag gaa gtg cgt etc ttc ttt ccg ctg cac etc 337
Gin Phe Pro Asp Gin Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu
95 100 105

tgg gtg aag aat gtg ttc eta aac cag act egg act cag cga gtc etc 385
Trp Val Lys Asn Val Phe Leu Asn Gin Thr Arg Thr Gin Arg Val Leu
110 115 120 125

ttt gtg gac agt gta gge ctg ccg get eee ccc agt ate ate aag gee 433
Phe Val Asp Ser Val Gly Leu Pro Ala Pro Pro Ser He He Lys Ala
130 135 140

atg ggt ggg age cag cca ggg gaa ett cag ate age tgg gag gag cca 481
Met Gly Gly Ser Gin Pro Gly Glu Leu Gin lie Ser Trp Glu Glu Pro
145 150 155

get cca gaa ate agt gat ttc ctg agg tac gaa etc egc tat gge ccc 529
Ala Pro Glu He Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro
160 165 170

aga gat ccc aag aac tee act ggt ccc aeg gtc ata cag ctg att gee 577
Arg Asp Pro Lys Asn Ser Thr Gly Pro Thr Val He Gin Leu He Ala
175 180 185

aca gaa acc tgc tgc cct get ctg cag aga cct cac tea gcc tct get 625
Thr Glu Thr Cys Cys Pro Ala Leu Gin Arg Pro His Ser Ala Ser Ala
190 195 200 205

ctg gac cag tct cca tgt get cag ccc aca atg ccc tgg caa gat gga 673
Leu Asp Gin Ser Pro Cys Ala Gin Pro Thr Met Pro Trp Gin Asp Gly
210 215 220

cea aag cag ace tec cca agt aga gaa get tea get ctg aca gea gag 721
Pro Lys Gin Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu
225 230 235

ggt gga age tgc etc ate tea gga etc cag cct gge aac tec tac tgg 769
Gly Gly Ser Cys Leu He Ser Gly Leu Gin Pro Gly Asn Ser Tyr Trp
240 245 250

Ctg cag ctg tge age gaa cct gat ggg ate tee etc ggt gge tec tgg 817
Leu Gin Leu Cys Ser Glu Pro Asp Gly He Ser Leu Gly Gly Ser Trp
255 260 265

gga tec tgg tec etc cct gtg act gtg gac ctg cct gga gat gea gtg 865
Gly Ser Trp Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val
270 275 280 285

gea ctt gga ctg caa tge ttt acc ttg gae ctg aag aat gtt acc tgt 913
Ala Leu Gly Leu Gin Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys
290 295 300

caa tgg cag caa cag gae cat get age tee caa gge ttc ttc tac cac 961

95

Gin Trp Gin Gin Gin Asp His Ala Ser Ser Gin Gly Phe Phe Tyr His
305 310 315

age agg gca egg tgc tgc ccc aga gac agg tac ccc ate tgg gag aae 1009
Ser Arg Ala Arg Cys Cys Pro Arg Asp Arg Tyr Pro lie Trp Glu Asn
320 325 330

tgc gaa gag gaa gag aaa aca aat cca gga eta cag aee eca cag tte 1057
Cys Glu Glu Glu Glu Lys Thr Asn Pro Gly Leu Gin Thr Pro Gin Phe
335 340 345

tct cge tge cac tte aag tea ega aat gac age att att cac ate ctt 1105
Ser Arg Cys His Phe Lys Ser Arg Asn Asp Ser lie lie His lie Leu
350 355 360 365

gtg gag gtg ace aca gee ccg ggt act gtt eac age tac ctg gge tec 1153
Val Glu Val Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser
370 375 380

cct tte tgg ate eac cag get gtg cge etc ccc ace cca aae ttg cac 1201
Pro Phe Trp lie His Gin Ala Val Arg Leu Pro Thr Pro Asn Leu His
385 390 395

tgg agg gag ate tec agt ggg eat ctg gaa ttg gag tgg cag eac eca 124 9

Trp Arg Glu lie Ser Ser Gly His Leu Glu Leu Glu Trp Gin His Pro
400 405 410

teg tec tgg gea gee caa gag ace tgt tat eaa etc ega tac aca gga 1297
Ser Ser Trp Ala Ala Gin Glu Thr Cys Tyr Gin Leu Arg Tyr Thr Gly
415 420 425

gaa gge eat cag gac tgg aag gtg ctg gag eeg cct etc ggg gee ega 1345
Glu Gly His Gin Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg
430 435 440 445

gga ggg ace ctg gag ctg cge eeg ega tct cge tac cgt tta cag ctg 1393
Gly Gly Thr Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gin Leu
450 455 460

cge gee agg etc aae gge ccc aee tac caa ggt ccc tgg age teg tgg 1441
Arg Ala Arg Leu Asn Gly Pro Thr Tyr Gin Gly Pro Trp Ser Ser Trp
465 470 475

teg gac cca act agg gtg gag acc gee acc gag aee gee tgg ate tec 14 8 9

Ser Asp Pro Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp lie Ser
480 485 490

ttg gtg ace get ctg eat eta gtg ctg gge etc age gee gtc ctg gge 1537
Leu Val Thr Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly
495 500 505

ctg ctg ctg ctg agg tgg cag ttt cct gea eac tac agg aga ctg agg 1585
Leu Leu Leu Leu Arg Trp Gin Phe Pro Ala His Tyr Arg Arg Leu Arg
510 515 520 525

cat gee ctg tgg ccc tea ett eca gac ctg cac egg gtc eta gge cag 1633
His Ala Leu Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gin

96

530 535 540

tac ctt agg gac act gca gcc ctg age ccg ccc aag gcc aca gtc tea 1681
Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser
545 550 555

gat acc tgt gaa gaa gtg gaa ccc age etc ett gaa ate etc ccc aag 1729
Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu lie Leu Pro Lys
560 565 570

tee tea gag agg act cet ttg eee ctg tgt tec tec cag gee eag atg 1777
Ser Ser Glu Arg Thr Pro Leu Pro Leu Cys Ser Ser Gin Ala Gin Met
575 580 585

gae tac ega aga ttg cag cet tet tge ctg ggg ace atg eee ctg tct 1825
Asp Tyr Arg Arg Leu Gin Pro Ser Cys Leu Gly Thr Met Pro Leu Ser
590 595 600 605

gtg tgc cca ccc atg get gag tea ggg tec tge tgt acc acc eac att 1873
Val Cys Pro Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His lie
610 615 620

gee aae eat tec tac eta cca eta age tat tgg cag cag cet tga 1918
Ala Asn His Ser Tyr Leu Pro Leu Ser Tyr Trp Gin Gin Pro
625 630 635

gtegae 1924

<210> 250

<211> 635

<212> PRT

<213> Homo sapiens

<400> 250

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala
15 10 15

r

Pro Gin Asn Leu Ala Gin Val Ser Ser Gin Asp Val Ser Leu Leu Ala
20 25 30

Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu
35 40 45

Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gin
50 55 60

Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser
65 70 75 80

Ser Gin Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys Gin Phe Pro

97

85 90 95

Asp Gin Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu Trp Val Lys
100 105 110

Asn Val Phe Leu Asn Gin Thr Arg Thr Gin Arg Val Leu Phe Val Asp
115 120 125

Ser Val Gly Leu Pro Ala Pro Pro Ser He He Lys Ala Met Gly Gly
130 135 140

Ser Gin Pro Gly Glu Leu Gin He Ser Trp Glu Glu Pro Ala Pro Glu
145 150 155 160

He Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro
165 170 175

Lys Asn Ser Thr Gly Pro Thr Val He Gin Leu He Ala Thr Glu Thr
180 185 190

Cys Cys Pro Ala Leu Gin Arg Pro His Ser Ala Ser Ala Leu Asp Gin
195 200 205

Ser Pro Cys Ala Gin Pro Thr Met Pro Trp Gin Asp Gly Pro Lys Gin
210 215 220

Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser
225 230 235 240

Cys Leu He Ser Gly Leu Gin Pro Gly Asn Ser Tyr Trp Leu Gin Leu
245 250 255

Cys Ser Glu Pro Asp Gly He Ser Leu Gly Gly Ser Trp Gly Ser Trp
260 265 270

Ser Leu Pro Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala Leu Gly
275 280 285

Leu Gin Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gin Trp Gin
290 295 300

Gin Gin Asp His Ala Ser Ser Gin Gly Phe Phe Tyr His Ser Arg Ala
305 310 315 320

98

Arg Cys Cys Pro Arg Asp Arg Tyr Pro lie Trp Glu Asn Cys Glu Glu
325 330 335

Glu Glu Lys Thr Asn Pro Gly Leu Gin Thr Pro Gin Phe Ser Arg Cys
340 345 350

His Phe Lys Ser Arg Asn Asp Ser lie lie His lie Leu Val Glu Val
355 360 365

Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser Pro Phe Trp
370 375 380

lie His Gin Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu
385 390 395 400

lie Ser Ser Gly His Leu Glu Leu Glu Trp Gin His Pro Ser Ser Trp
405 410 415

Ala Ala Gin Glu Thr Cys Tyr Gin Leu Arg Tyr Thr Gly Glu Gly His
420 425 430

Gin Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr
435 440 445

Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gin Leu Arg Ala Arg
450 455 460

Leu Asn Gly Pro Thr Tyr Gin Gly Pro Trp Ser Ser Trp Ser Asp Pro
465 470 475 480

Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp lie Ser Leu Val Thr
485 490 495

Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu
500 505 510

Leu Arg Trp Gin Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu
515 520 525

Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gin Tyr Leu Arg
530 535 540

99

Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys
545 550 555 560

Glu Glu Val Glu Pro Ser Leu Leu Glu lie Leu Pro Lys Ser Ser Glu
565 570 575

Arg Thr Pro Leu Pro Leu Cys Ser Ser Gin Ala Gin Met Asp Tyr Arg
580 585 590

Arg Leu Gin Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro
595 600 605

Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His lie Ala Asn His
610 615 620

Ser Tyr Leu Pro Leu Ser Tyr Trp Gin Gin Pro
625 630 635

<210> 251

<211> 1924

<212> DNA

<213> Homo sapiens

<220>

<221> CDS

<222> (11) . . (1918)

<400> 251

gaattccacc atg ccc tec tgg gcc etc ttc atg gtc ace tec tge etc 49
Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu
15 10

etc ctg gee cet eaa aac etg gcc caa gtc age age caa gat gtc tec 97
Leu Leu Ala Pro Gin Asn Leu Ala Gin Val Ser Ser Gin Asp Val Ser
15 20 25

ttg ctg gea tea gae tea gag ccc ctg aag tgt ttc tec ega aca ttt 145
Leu Leu Ala Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe
30 35 40 45

gag gae etc act tgc ttc tgg gat gag gaa gag gca geg ccc agt ggg 193
Glu Asp Leu Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly
50 55 60

aca tac cag etg ctg tat gee tac ecg egg gag aag ccc egt get tge 241
Thr Tyr Gin Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys
65 70 75

ccc ctg agt tec cag age atg ccc cac ttt gga ace ega tac gtg tgc 289
Pro Leu Ser Ser Gin Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys

100

80 85 90

cag ttt cca gac cag gag gaa gtg cgt etc ttc ttt ccg ctg cac etc 337
Gin Phe Pro Asp Gin Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu
95 100 105

tgg gtg aag aat gtg ttc eta aae eag act egg act eag cga gtc etc 385
Trp Val Lys Asn Val Phe Leu Asn Gin Thr Arg Thr Gin Arg Val Leu
110 115 120 125

ttt gtg gac agt gta gge etg ccg get cec ecc agt ate ate aag gee 433
Phe Val Asp Ser Val Gly Leu Pro Ala Pro Pro Ser lie lie Lys Ala
130 135 140

atg ggt ggg age cag cea ggg gaa ett cag ate age tgg gag gag cca 481
Met Gly Gly Ser Gin Pro Gly Glu Leu Gin lie Ser Trp Glu Glu Pro
145 150 155

get cea gaa ate agt gat tte etg agg tae gaa etc cge tat gge eee 529
Ala Pro Glu He Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro
160 165 170

aga gat eee aag aac tec act ggt cec acg gte ata eag etg att gee 577
Arg Asp Pro Lys Asn Ser Thr Gly Pro Thr Val He Gin Leu He Ala
175 180 185

aea gaa ace tge tge ect get etg eag aga cet eae tea gee tet get 625
Thr Glu Thr Cys Cys Pro Ala Leu Gin Arg Pro His Ser Ala Ser Ala
190 195 200 205

etg gae eag tet cea tgt get eag eee aca atg ecc tgg eaa gat gga 673
Leu Asp Gin Ser Pro Cys Ala Gin Pro Thr Met Pro Trp Gin Asp Gly
210 215 220

cca aag eag ace tee eca agt aga gaa get tea get etg aea gea gag 721
Pro Lys Gin Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu
225 230 235

ggt gga age tge etc ate tea gga etc eag ect gge aac tec tae tgg 769
Gly Gly Ser Cys Leu He Ser Gly Leu Gin Pro Gly Asn Ser Tyr Trp
240 245 250

Ctg cag ctg ege age gaa ect gat ggg ate tee etc ggt gge tec tgg 817
Leu Gin Leu Arg Ser Glu Pro Asp Gly He Ser Leu Gly Gly Ser Trp
255 260 265

gga tee tgg tee etc act gtg act gtg gac ctg ect gga gat gea gtg 865
Gly Ser Trp Ser Leu Thr Val Thr Val Asp Leu Pro Gly Asp Ala Val
270 275 280 285

gea ett gga etg eaa tge ttt acc ttg gac ctg aag aat gtt aee tgt 913
Ala Leu Gly Leu Gin Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys
290 295 300

eaa tgg eag eaa eag gac eat get age tec eaa gge tte tte tae eae 961
Gin Trp Gin Gin Gin Asp His Ala Ser Ser Gin Gly Phe Phe Tyr His
305 310 315

101

age agg gca
Ser Arg Ala
320

tgc gaa gag
Cys Glu Glu
335

tct cgc tgc
Ser Arg Cys
350

gtg gag gtg
Val Glu Val

cct ttc tgg
Pro Phe Trp

tgg agg gag
Trp Arg Glu
400

teg tee tgg
Ser Ser Trp
415

gaa ggc eat
Glu Gly His
430

gga ggg aee
Gly Gly Thr

egc gee agg
Arg Ala Arg

teg gae eea
Ser Asp Pro
480

ttg gtg acc
Leu Val Thr
495

ctg etg etg
Leu Leu Leu
510

eat gee etg
His Ala Leu

egg tgc tgc
Arg Cys Cys

gaa gag aaa
Glu Glu Lys

cae ttc aag
His Phe Lys
355

acc aca gee
Thr Thr Ala
370

ate cae eag
lie His Gin
385

ate tec agt
lie Ser Ser

gea gee caa
Ala Ala Gin

cag gae tgg
Gin Asp Trp
435

etg gag ctg
Leu Glu Leu
450

etc aac ggc
Leu Asn Gly
465

act agg gtg
Thr Arg Val

get etg cat
Ala Leu His

etg agg tgg
Leu Arg Trp
515

tgg eee tea
Trp Pro Ser
530

ccc aga gae
Pro Arg Asp
325

aca aat eea
Thr Asn Pro
340

tea ega aat
Ser Arg Asn

eeg ggt act
Pro Gly Thr

get gtg cgc
Ala Val Arg
390

ggg cat ctg
Gly His Leu
405

gag aee tgt
Glu Thr Cys
420

aag gtg ctg
Lys Val Leu

ege eeg cga
Arg Pro Arg

ccc aee tac
Pro Thr Tyr
470

gag aee gee
Glu Thr Ala
485

eta gtg ctg
Leu Val Leu
500

cag ttt cct
Gin Phe Pro

ett cca gae
Leu Pro Asp

agg tac ccc
Arg Tyr Pro

gga eta eag
Gly Leu Gin
345

gae age att
Asp Ser lie
360

gtt eac age
Val His Ser
375

etc ccc aee
Leu Pro Thr

gaa ttg gag
Glu Leu Glu

tat caa etc
Tyr Gin Leu
425

gag eeg eet
Glu Pro Pro
440

tct egc tac
Ser Arg Tyr
455

caa ggt ccc
Gin Gly Pro

acc gag acc
Thr Glu Thr

ggc etc age
Gly Leu Ser
505

gca cae tac
Ala His Tyr
520

etg eac egg
Leu His Arg
535

ate tgg gag
lie Trp Glu
330

aee eea cag
Thr Pro Gin

att cae ate
lie His He

tac ctg gge
Tyr Leu Gly
380

cca aac ttg
Pro Asn Leu
395

tgg eag cac
Trp Gin His
410

ega tac aca
Arg Tyr Thr

etc ggg gee
Leu Gly Ala

egt tta cag
Arg Leu Gin
460

tgg age teg
Trp Ser Ser
475

gee tgg ate
Ala Trp He
490

gee gtc ctg
Ala Val Leu

agg aga etg
Arg Arg Leu

gtc eta gge
Val Leu Gly
540

aac 1009
Asn

ttc 1057
Phe

ett 1105

Leu

365

tec 1153
Ser

cac 1201
His

cca 1249
Pro

gga 1297
Gly

ega 1345

Arg

445

ctg 1393
Leu

tgg 1441
Trp

tee 1489
Ser

ggc 1537
Gly

agg 1585

Arg

525

cag 1633
Gin

102

tac ctt agg gac act gca gcc ctg age ccg ccc aag gcc aca gtc tea 1681
Tyr Leu Arg Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser
545 550 555

gat acc tgt gaa gaa gtg gaa ccc age etc ctt gaa ate etc eee aag 1729
Asp Thr Cys Glu Glu Val Glu Pro Ser Leu Leu Glu lie Leu Pro Lys
560 565 570

tec tea gag agg act ect ttg ccc ctg tgt tee tee eag gee eag atg 1777
Ser Ser Glu Arg Thr Pro Leu Pro Leu Cys Ser Ser Gin Ala Gin Met
575 580 585

gae tac ega aga ttg eag cct tct tgc ctg ggg acc atg ccc ctg tct 1825
Asp Tyr Arg Arg Leu Gin Pro Ser Cys Leu Gly Thr Met Pro Leu Ser
590 595 600 605

gtg tgc cea ccc atg get gag tea ggg tec tgc tgt acc acc cae att 1873
Val Cys Pro Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His lie
610 615 620

gcc aac cat tee tac eta cca eta age tat tgg eag eag ect tga 1918
Ala Asn His Ser Tyr Leu Pro Leu Ser Tyr Trp Gin Gin Pro
625 630 635

gtcgac 1924

<210> 252

<211> 635

<212> PRT

<213> Homo sapiens

<400> 252

Met Pro Ser Trp Ala Leu Phe Met Val Thr Ser Cys Leu Leu Leu Ala
15 10 15

Pro Gin Asn Leu Ala Gin Val Ser Ser Gin Asp Val Ser Leu Leu Ala
20 25 30

Ser Asp Ser Glu Pro Leu Lys Cys Phe Ser Arg Thr Phe Glu Asp Leu
35 40 45

Thr Cys Phe Trp Asp Glu Glu Glu Ala Ala Pro Ser Gly Thr Tyr Gin
50 55 60

Leu Leu Tyr Ala Tyr Pro Arg Glu Lys Pro Arg Ala Cys Pro Leu Ser
65 70 75 80

Ser Gin Ser Met Pro His Phe Gly Thr Arg Tyr Val Cys Gin Phe Pro
85 90 95

103

Asp Gin Glu Glu Val Arg Leu Phe Phe Pro Leu His Leu Trp Val Lys
100 105 110

Asn Val Phe Leu Asn Gin Thr Arg Thr Gin Arg Val Leu Phe Val Asp
115 120 125

Ser Val Gly Leu Pro Ala Pro Pro Ser lie lie Lys Ala Met Gly Gly
130 135 140

Ser Gin Pro Gly Glu Leu Gin lie Ser Trp Glu Glu Pro Ala Pro Glu
145 150 155 160

lie Ser Asp Phe Leu Arg Tyr Glu Leu Arg Tyr Gly Pro Arg Asp Pro
165 170 175

Lys Asn Ser Thr Gly Pro Thr Val lie Gin Leu lie Ala Thr Glu Thr
180 185 190

Cys Cys Pro Ala Leu Gin Arg Pro His Ser Ala Ser Ala Leu Asp Gin
195 200 205

Ser Pro Cys Ala Gin Pro Thr Met Pro Trp Gin Asp Gly Pro Lys Gin
210 215 220

Thr Ser Pro Ser Arg Glu Ala Ser Ala Leu Thr Ala Glu Gly Gly Ser
225 230 235 240

Cys Leu lie Ser Gly Leu Gin Pro Gly Asn Ser Tyr Trp Leu Gin Leu
245 250 255

Arg Ser Glu Pro Asp Gly lie Ser Leu Gly Gly Ser Trp Gly Ser Trp
260 265 270

Ser Leu Thr Val Thr Val Asp Leu Pro Gly Asp Ala Val Ala Leu Gly
275 280 285

Leu Gin Cys Phe Thr Leu Asp Leu Lys Asn Val Thr Cys Gin Trp Gin
290 295 300

Gin Gin Asp His Ala Ser Ser Gin Gly Phe Phe Tyr His Ser Arg Ala
305 310 315 320

104

Arg Cys Cys Pro Arg Asp Arg Tyr Pro He Trp Glu Asn Cys Glu Glu
325 330 335

Glu Glu Lys Thr Asn Pro Gly Leu Gin Thr Pro Gin Phe Ser Arg Cys
340 345 350

His Phe Lys Ser Arg Asn Asp Ser He He His He Leu Val Glu Val
355 360 365

Thr Thr Ala Pro Gly Thr Val His Ser Tyr Leu Gly Ser Pro Phe Trp
370 375 380

He His Gin Ala Val Arg Leu Pro Thr Pro Asn Leu His Trp Arg Glu
385 390 395 400

He Ser Ser Gly His Leu Glu Leu Glu Trp Gin His Pro Ser Ser Trp
405 410 415

Ala Ala Gin Glu Thr Cys Tyr Gin Leu Arg Tyr Thr Gly Glu Gly His
420 425 430

Gin Asp Trp Lys Val Leu Glu Pro Pro Leu Gly Ala Arg Gly Gly Thr
435 440 445

Leu Glu Leu Arg Pro Arg Ser Arg Tyr Arg Leu Gin Leu Arg Ala Arg
450 455 460

Leu Asn Gly Pro Thr Tyr Gin Gly Pro Trp Ser Ser Trp Ser Asp Pro
465 470 475 480

Thr Arg Val Glu Thr Ala Thr Glu Thr Ala Trp He Ser Leu Val Thr
485 490 495

Ala Leu His Leu Val Leu Gly Leu Ser Ala Val Leu Gly Leu Leu Leu
500 505 510

Leu Arg Trp Gin Phe Pro Ala His Tyr Arg Arg Leu Arg His Ala Leu
515 520 525

Trp Pro Ser Leu Pro Asp Leu His Arg Val Leu Gly Gin Tyr Leu Arg
530 535 540

Asp Thr Ala Ala Leu Ser Pro Pro Lys Ala Thr Val Ser Asp Thr Cys

105

545 550 555 560

Glu Glu Val Glu Pro Ser Leu Leu Glu lie Leu Pro Lys Ser Ser Glu
565 570 575

Arg Thr Pro Leu Pro Leu Cys Ser Ser Gin Ala Gin Met Asp Tyr Arg
580 585 590

Arg Leu Gin Pro Ser Cys Leu Gly Thr Met Pro Leu Ser Val Cys Pro
595 600 605

Pro Met Ala Glu Ser Gly Ser Cys Cys Thr Thr His lie Ala Asn His
610 615 620

Ser Tyr Leu Pro Leu Ser Tyr Trp Gin Gin Pro

<210> 253

<211> 1572

<212> DNA

<213> Homo sapiens

<400> 253

atggactgga cctggaggtt cctctttgtg gtggcagcag ctacaggtgt ccagtcccag 60

gtgcagctgg tgcagtctgg acctgaggtg aagaagcctg gggcctcagt gaaggtctcc 12 0

tgcaaggctt ctggatacac cttcaccaac tcctggatga actgggtgag gcagaggcct 180

ggaaagggtc ttgagtgggt tggacggatt tatcctggag atggagaaac tatctacaat 24 0

gggaaattca gggtcagagt cacgattacc gcggacgaat ccacgagcac agcctacatg 300

gagctgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag aggctatgat 360

gattactcgt ttgcttactg gggccaggga accacggtca ccgtctcttc aggtggtggt 42 0

ggatccggag gtggtggatc gggtggtgga ggatcggata ttgtgatgac tcagtctgca 480

ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtaagagt 540

ctcctgcata gtaatggcaa cacttacttg tattggtacc tgcagaagcc agggcagtct 600

ccacagctcc tgatctatcg gatgtccaac cttgcctcag gggtccctga caggttcagt 660

ggcagtggat caggcacagc ttttacactg aaaatcagca gagtggaggc tgaggatgtt 72 0

ggggtttatt actgcatgca acatatagaa tatcctttta cgttcggcca agggaccaaa 780

ctggaaatca aaggaggtgg tggatcgggt ggtggtggtt cgggaggcgg tggatcgcag 84 0

106

gtgcagctgg

tgcagtctgg acctgaggtg

aagaagcctg

gggcctcagt

gaaggtctcc

900

tgcaaggctt

ctggatacac cttcaccaac

tcctggatga

actgggtgag

gcagaggcct

960

ggaaagggtc

ttgagtgggt tggacggatt

tatcctggag

atggagaaac

tatctacaat

1020

gggaaattca

gggtcagagt cacgattacc

gcggacgaat

ccacgagcac

agcctacatg

1080

gagctgagca

gcctgagatc tgaggacacg

gccgtgtatt

actgtgcgag

aggctatgat

1140

gattactcgt

ttgcttactg gggccaggga

accacggtca

ccgtctcttc

aggtggtggt

1200

ggatccggag

gtggtggatc gggtggtgga

ggatcggata

ttgtgatgac

tcagtctgca

1260

ctctccctgc

ccgtcacccc tggagagccg

gcctccatct

cctgcaggtc

tagtaagagt

1320

ctcctgcata

gtaatggcaa cacttacttg

tattggtacc

tgcagaagcc

agggcagtct

1380

ccacagctcc

tgatctatcg gatgtccaac

cttgcctcag

gggtccctga

caggttcagt

1440

ggcagtggat

caggcacagc ttttacactg

aaaatcagca

gagtggaggc

tgaggatgtt

1500

ggggtttatt

actgcatgca acatatagaa

tatcctttta

cgttcggcca

agggaccaaa

1560

ctggaaatca

aa

1572

<210> 254
<211> 524
<212> PRT
<:2 T 3 > Hnmn

-I- ^ ^ XX\JWW^

i sapiens

<400> 254

M^t" AcjD T'm

1

Thr Trp Arg Phe Leu Phe Val Val
5 10

ala ala aTa
nj-d n-LOi t\l.aL

iiiiL oxy
15

Val Gin 'JPT-

Gin Val Gin Leu Val Gin Ser Gly
20 25

fro (a±u vax
30

Lys Lys

Pto m V Al ;^
35

Ser Val Lys Val Ser Cys Lys Ala
40

oei: oXy Xyi
45

inr fne

Thr Asn Ser

Trp Met Asn Trp Val Arg Gin Arg
55

Pro Gly Lys

O U

Gly Leu

Gly Arg lie Tyr Pro Gly Asp Gly

(^Ti-i 'PVii- Tli?i

tjiu inr lie

Tyr Asn

65

70

75

80

Gly Lys Phe

Arg Val Arg Val Thr He Thr Ala
85 90

Asp Glu Ser

Thr Ser
95

107

Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
100 105 110

Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly
115 120 125

Gin Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
130 135 140

Gly Gly Ser Gly Gly Gly Gly Ser Asp lie Val Met Thr Gin Ser Ala
145 150 155 160

Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser lie Ser Cys Arg
165 170 175

Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp
180 185 190

Tyr Leu Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu lie Tyr Arg Met
195 200 205

Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser
210 215 220

Gly Thr Ala Phe Thr Leu Lys He Ser Arg Val Glu Ala Glu Asp Val
225 230 235 240

Gly Val Tyr Tyr Cys Met Gin His He Glu Tyr Pro Phe Thr Phe Gly
245 250 255

Gin Gly Thr Lys Leu Glu He Lys Gly Gly Gly Gly Ser Gly Gly Gly
260 265 270

Gly Ser Gly Gly Gly Gly Ser Gin Val Gin Leu Val Gin Ser Gly Pro
275 280 285

Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
290 295 300

Gly Tyr Thr Phe Thr Asn Ser Trp Met Asn Trp Val Arg Gin Arg Pro
305 310 315 320

108

Gly Lys Gly Leu Glu Trp Val Gly Arg lie Tyr Pro Gly Asp Gly Glu
325 330 335

Thr lie Tyr Asn Gly Lys Phe Arg Val Arg Val Thr lie Thr Ala Asp
340 345 350

Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu
355 360 365

Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe
370 375 380

Ala Tyr Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
385 390 395 400

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp lie Val Met
405 410 415

Thr Gin Ser Ala Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser
420 425 430

lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr
435 440 445

Tyr Leu Tyr Trp Tyr Leu Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu
450 455 460

lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser
465 470 475 480

Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys lie Ser Arg Val Glu
485 490 495

Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His lie Glu Tyr Pro
500 505 510

Phe Thr Phe Gly Gin Gly Thr Lys Leu Glu lie Lys
515 520

<210> 255

<211> 354

<212> DNA

<213> Homo sapiens

109

<400> 255

caggtgcagc tggtgcagtc tggacctgag gtgaagaagc ctggggcctc agtgaaggtc 60

tcctgcaagg cttctggata caccttcacc aactcctgga tgaactgggt gaggcagagg 120

cctggaaagg gtcttgagtg ggttggacgg atttatcctg gagatggaga aactatctac 180

aatgggaaat tcagggtcag agtcacgatt accgcggacg aatccacgag cacagcctac 240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctat 3 00

gatgattact cgtttgctta ctggggccag ggaaccacgg tcaccgtctc ttca 354

<210> 256

<211> 118

<212> PRT

<213> Homo sapiens

<400> 256

Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
15 10 15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser
20 25 30

Trp Met Asn Trp Val Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp Val
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr He Tyr Asn Gly Lys Phe
50 55 60

Arg Val Arg Val Thr He Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95

Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Thr Val Thr Val Ser Ser
115

<210> 257
<211> 336
<212> DNA

110

<213> Homo sapiens
<400> 257

gatattgtga tgactcagtc tgcactctcc ctgcccgtca cccctggaga gccggcctcc 60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg 120

tacctgcaga agccagggca gtctccacag ctcctgatct atcggatgtc caaccttgcc 180

tcaggggtcc ctgacaggtt cagtggcagt ggatcaggca cagcttttac actgaaaatc 24 0

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaacatat agaatatcct 300

tttacgttcg gccaagggac caaactggaa atcaaa 336

<210> 258

<2.11> 112

<212> PRT

<213> Homo sapiens

<400> 258

Asp lie Val Met Thr Gin Ser Ala Leu Ser Leu Pro Val Thr Pro Gly
15 10 15

Glu Pro Ala Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Tyr Leu Gin Lys Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys lie
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

lie Glu Tyr Pro Phe Thr Phe Gly Gin Gly Thr Lys Leu Glu lie Lys
100 105 110

<210> 259

<211> 1572

<212> DNA

<213> Homo sapiens

<400> 259

Ill

atggactgga

cctggaggtt

cctctttgtg

gtggcagcag

ctacaggtgt

ccagtcccag

60

gtgcagctgg

tgcagtctgg

acctgaggtg

aagaagcctg

gggcctcagt

gaaggtctcc

120

tgcaaggctt

ctggatacac

cttcaccaac

tcctggatga

actggatcag

gcagaggcct

180

ggaaagggtc

ttgagtggat

tggacggatt

tatcctggag

atggagaaac

tatctacaat

240

gggaaattca

gggtcagagt

cacgattacc

gcggacgaat

ccacgagcac

agcctacatg

300

gagctgagca

gcctgagatc

tgaggacacg

gccgtgtatt

actgtgcgag

aggctatgat

360

gattactcgt

ttgcttactg

gggccaggga

accctggtca

ccgtctcttc

aggtggtggt

420

ggatccggag

gtggtggatc

gggtggtgga

ggatcggata

ttgtgatgac

tcagtctgca

480

ctctccctgc

ccgtcacccc

tggagagccg

gcctccatct

cctgcaggtc

tagtaagagt

540

ctcctgcata

gtaatggcaa

cacttacttg

tattggtacc

tgcagaagcc

agggcagtct

600

ccacagctcc

tgatctatcg

gatgtccaac

cttgcctcag

gggtccctga

caggttcagt

660

ggcagtggat

caggcacagc

ttttacactg

aaaatcagca

gagtggaggc

tgaggatgtt

720

ggggtttatt

actgcatgca

acatatagaa

tatcctttta

cgttcggcca

agggaccaaa

780

ctggaaatca

aaggaggtgg

tggatcgggt

ggtggtggtt

cgggaggcgg

tggatcgcag

840

gtgcagctgg

tgcagtctgg

acctgaggtg

aagaagcctg

gggcctcagt

gaaggtctcc

900

tgcaaggctt

ctggatacac

cttcaccaac

tcctggatga

actggatcag

gcagaggcct

960

ggaaagggtc

ttgagtggat

tggacggatt

tatcctggag

atggagaaac

tatctacaat

1020

gggaaattca

gggtcagagt

cacgattacc

gcggacgaat

ccacgagcac

agcctacatg

1080

gagctgagca

gcctgagatc

tgaggacacg

gccgtgtatt

actgtgcgag

aggctatgat

1140

gattactcgt

ttgcttactg

gggccaggga

accctggtca

ccgtctcttc

aggtggtggt

1200

ggatccggag

gtggtggatc

gggtggtgga

ggatcggata

ttgtgatgac

tcagtctgca

1260

ctctccctgc

ccgtcacccc

tggagagccg

gcctccatct

cctgcaggtc

tagtaagagt

1320

ctcctgcata

gtaatggcaa

cacttacttg

tattggtacc

tgcagaagcc

agggcagtct

1380

ccacagctcc

taatctatca

ciat"crt"PPaar'

^-J t-l ^ — ] ' — ^ — \^ CICL^

L- »— ^ L.^C1.

1 4. J. n

X *± *± u

ggcagtggat

caggcacagc

ttttacactg

aaaatcagca

gagtggaggc

tgaggatgtt

1500

ggggtttatt

actgcatgca

acatatagaa

tatcctttta

cgttcggcca

agggaccaaa

1560

ctggaaatca

aa

1572

<210>

260

112

<211> 524
<212> PRT
<213> Homo sapiens

<400> 260

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly
15 10 15

Val Gin Ser Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys
20 25 30

Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
35 40 45

Thr Asn Ser Trp Met Asn Trp lie Arg Gin Arg Pro Gly Lys Gly Leu
50 55 60

Glu Trp lie Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn
65 70 75 80

Gly Lys Phe Arg Val Arg Val Thr lie Thr Ala Asp Glu Ser Thr Ser
85 90 95

Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
100 105 110

Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly
115 120 125

Gin Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
130 135 140

Gly Gly Ser Gly Gly Gly Gly Ser Asp lie Val Met Thr Gin Ser Ala
145 150 155 160

Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser lie Ser Cys Arg
165 170 175

Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp
180 185 190

Tyr Leu Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu lie Tyr Arg Met
195 200 205

113

Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser
210 215 220

Gly Thr Ala Phe Thr Leu Lys lie Ser Arg Val Glu Ala Glu Asp Val
225 230 235 240

Gly Val Tyr Tyr Cys Met Gin His lie Glu Tyr Pro Phe Thr Phe Gly
245 250 255

Gin Gly Thr Lys Leu Glu lie Lys Gly Gly Gly Gly Ser Gly Gly Gly
260 265 270

Gly Ser Gly Gly Gly Gly Ser Gin Val Gin Leu Val Gin Ser Gly Pro
275 280 285

Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
290 295 300

Gly Tyr Thr Phe Thr Asn Ser Trp Met Asn Trp lie Arg Gin Arg Pro
305 310 315 320

Gly Lys Gly Leu Glu Trp lie Gly Arg lie Tyr Pro Gly Asp Gly Glu
325 330 335

Thr He Tyr Asn Gly Lys Phe Arg Val Arg Val Thr He Thr Ala Asp
340 345 350

Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu
355 360 365

Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe
370 375 380

Ala Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly
385 390 395 400

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp He Val Met
405 410 415

Thr Gin Ser Ala Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser
420 425 430

114

He Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr
435 440 445

Tyr Leu Tyr Trp Tyr Leu Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu
450 455 460

He Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser
465 470 475 480

Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys lie Ser Arg Val Glu
485 490 495

Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His He Glu Tyr Pro
500 505 510

Phe Thr Phe Gly Gin Gly Thr Lys Leu Glu He Lys
515 520

<210> 261

<211> 354

<212> DNA

<213> Homo sapiens

<400> 261

caggtgcagc tggtgcagtc tggacctgag gtgaagaagc ctggggcctc agtgaaggtc 60

tcctgcaagg cttctggata caccttcacc aactcctgga tgaactggat caggcagagg 120

cctggaaagg gtcttgagtg gattggacgg atttatcctg gagatggaga aactatctac 180

aatgggaaat tcagggtcag agtcacgatt accgcggacg aatccacgag cacagcctac 240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctat 300

gatgattact cgtttgctta ctggggccag ggaaccctgg tcaccgtctc ttca 354

<210> 262

<211> 118

<212> PRT

<213> Homo sapiens

<400> 262

Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
15 10 15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser
20 25 30

115

Trp Met Asn Trp lie Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe
50 55 60

Arg Val Arg Val Thr lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95

Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr

Leu Val Thr Val Ser Ser
115

<210> 263

<211> 1572

<212> DNA

<213> Mus musculus

<400> 263

atggaatggc ctttgatctt tctcttcctc ctgtcaggaa ctgcaggtgt ccactcccag 60

gttcagctgc agcagtctgg acctgagctg gtgaagcctg gggcctcagt gaagatttcc 12 0

tgcaaggctt ctggctatgc attcactaac tcctggatga actgggtgaa gcagaggcct 180

ggaaagggtc ttgagtggat tggacggatt tatcctggag atggagaaac tatctacaat 24 0

gggaaattca gggtcaaggc cacactgact gcagacaaat cctccagcac agcctacatg 300

gatatcagca gcctgacatc tgaggactct gcggtctact tctgtgcaag aggctatgat 360

gattactcgt ttgcttactg gggccaaggg actctggtca ctgtctctgc aggtggtggt 420

ggttcgggtg gtggtggttc gggtggtggc ggatcggata ttgtgatgac tcaggctgca 4 80

ccctctatac ctgtcactcc tggagagtca gtatccatct cctgtaggtc tagtaagagt 540

ctcctgcata gtaatggcaa cacttacttg tattggttcc tgcagaggcc aggccagtct 600

cctcaactcc tgatatatcg gatgtccaac cttgcctcag gagtcccaga taggttcagt 660

ggcagtgggt caggaactgc tttcacactg agaatcagta gagtggaggc tgaggatgtg 720

ggtgtttatt actgtatgca acatatagaa tatcctttta cgttcggatc ggggaccaag 780

116

ctggaaataa

aaggaggtgg

tggatcgggt

ggtggtggtt

cgggaggcgg

tggatcgcag

840

gttcagctgc

agcagtctgg

acctgagctg

gtgaagcctg

gggcctcagt

gaagatttcc

900

tgcaaggctt

ctggctatgc

attcactaac

tcctggatga

actgggtgaa

gcagaggcct

960

ggaaagggtc

ttgagtggat

tggacggatt

tatcctggag

atggagaaac

tatctacaat

1020

gggaaattca

gggtcaaggc

cacactgact

gcagacaaat

cctccagcac

agcctacatg

1080

gatatcagca

gcctgacatc

tgaggactct

gcggtctact

tctgtgcaag

aggctatgat

1140

gattactcgt

ttgcttactg

gggccaaggg

actctggtca

ctgtctctgc

aggtggtggt

1200

ggttcgggtg

gtggtggttc

gggtggtggc

ggatcggata

ttgtgatgac

tcaggctgca

1260

ccctctatac

ctgtcactcc

tggagagtca

gtatccatct

cctgtaggtc

tagtaagagt

1320

ctcctgcata

gtaatggcaa

cacttacttg

tattggttcc

tgcagaggcc

aggccagtct

1380

Ld^^ L. UCd^ t.

ggcagtgggt

caggaactgc

tttcacactg

agaatcagta

gagtggaggc

tgaggatgtg

1500

ggtgtttatt

actgtatgca

acatatagaa

tatcctttta

cgttcggatc

ggggaccaag

1560

ctggaaataa

aa

1572

<210> 264

<211> 524

<212> PRT

<213> Mus musculus

<400> 264

Met Glu Trp Pro Leu lie Phe Leu Phe Leu Leu Ser Gly Thr Ala Gly
15 10 15

Val His Ser Gin Val Gin Leu Gin Gin Ser Gly Pro Glu Leu Val Lys
20 25 30

Pro Gly Ala Ser Val Lys lie Ser Cys Lys Ala Ser Gly Tyr Ala Phe
35 40 45

Thr Asn Ser Trp Met Asn Trp Val Lys Gin Arg Pro Gly Lys Gly Leu
50 55 60

Glu Trp lie Gly Arg He Tyr Pro Gly Asp Gly Glu Thr He Tyr Asn
65 70 75 80

Gly Lys Phe Arg Val Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser

117

85

90

95

Thr Ala Tyr Met Asp lie Ser Ser Leu Thr Ser Glu Asp Ser Ala Val
100 105 110

Tyr Phe Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly
115 120 125

Gin Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly Gly Ser Gly Gly
130 135 140

Gly Gly Ser Gly Gly Gly Gly Ser Asp He Val Met Thr Gin Ala Ala
145 150 155 160

Pro Ser He Pro Val Thr Pro Gly Glu Ser Val Ser He Ser Cys Arg
165 170 175

Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp
180 185 190

Phe Leu Gin Arg Pro Gly Gin Ser Pro Gin Leu Leu He Tyr Arg Met
195 200 205

Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser
210 215 220

Gly Thr Ala Phe Thr Leu Arg He Ser Arg Val Glu Ala Glu Asp Val
225 230 235 240

Gly Val Tyr Tyr Cys Met Gin His He Glu Tyr Pro Phe Thr Phe Gly
245 250 255

Ser Gly Thr Lys Leu Glu He Lys Gly Gly Gly Gly Ser Gly Gly Gly
260 265 270

Gly Ser Gly Gly Gly Gly Ser Gin Val Gin Leu Gin Gin Ser Gly Pro
275 280 285

Glu Leu Val Lys Pro Gly Ala Ser Val Lys He Ser Cys Lys Ala Ser
290 295 300

Gly Tyr Ala Phe Thr Asn Ser Trp Met Asn Trp Val Lys Gin Arg Pro
305 310 315 320

118

o

Gly Lys Gly Leu Glu Trp lie Gly Arg lie Tyr Pro Gly Asp Gly Glu
325 330 335

Thr lie Tyr Asn Gly Lys Phe Arg Val Lys Ala Thr Leu Thr Ala Asp
340 345 350

Lys Ser Ser Ser Thr Ala Tyr Met Asp lie Ser Ser Leu Thr Ser Glu
355 360 365

Asp Ser Ala Val Tyr Phe Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe
370 375 380

Ala Tyr Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ala Gly Gly Gly
385 390 395 400

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp lie Val Met
405 410 415

Thr Gin Ala Ala Pro Ser lie Pro Val Thr Pro Gly Glu Ser Val Ser
420 425 430

lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr
435 440 445

Tyr Leu Tyr Trp Phe Leu Gin Arg Pro Gly Gin Ser Pro Gin Leu Leu
450 455 460

lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser
465 470 475 480

Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg He Ser Arg Val Glu
485 490 495

Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His He Glu Tyr Pro
500 505 510

Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu He Lys
515 520

<210> 265
<211> 30

119

<212> PRT

<213> Homo sapiens

<400> 265

Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
1 5 - 10 15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
20 25 30

<210> 266

<211> 5

<212> PRT

<213> Homo sapiens

<400> 266

Asn Ser Trp Met Asn
1 5

<210> 267

<211> 14

<212> PRT

<213> Homo sapiens

<400> 267

Trp Val Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp Val Gly
15 10

<210> 268

<211> 17

<212> PRT

<213> Homo sapiens

<400> 268

Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe Arg
15 10 15

Val

<210> 269

<211> 32

<212> PRT

<213> Homo sapiens

<400> 269

120

Arg Val Thr He Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu
15 10 15

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
20 25 30

<210>

270

<211>

9

<212>

PRT

<213>

Homo

<400>

270

Gly Tyr Asp

1

<210>

271

<211>

11

<212>

PRT

<213>

Homo

<400>

271

Trp Gly Gin

1

<210>

272

<211>

23

<212>

PRT

<213>

Homo

<400>

272

10

Asp He Val Met Thr Gin Ser Ala Leu Ser Leu Pro Val Thr Pro Gly
15 10 15

Glu Pro Ala Ser He Ser Cys
20

<210> 273

<211> 16

<212> PRT

<213> Homo sapiens

<400> 273

Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr
15 10 15

<210> 274

121

<211> 15

<212> PRT

<213> Homo sapiens

<400> 274

Trp Tyr Leu Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu lie Tyr
15 10 15

<210> 275

<211> 7

<212> PRT

<213> Homo sapiens

<400> 275

Arg Met Ser Asn Leu Ala Ser
1 5

<210> 276

<211> 32

<212> PRT

<213> Homo sapiens

<400> 276

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr
15 10 15

Leu Lys lie Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
20 25 30

<210> 277

<211> 9

<212> PRT

<213> Homo sapiens

<400> 277

Met Gin His lie Glu Tyr Pro Phe Thr
1 5

<210> 278

<211> 10

<212> PRT

<213> Homo sapiens

<400> 278

Phe Gly Gin Gly Thr Lys Leu Glu lie Lys
15 10

122

<210> 279

<211> 30

<212> PRT

<213> Homo sapiens

<400> 279

Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
1 5 10 15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
20 25 30

<210> 280

<211> 5

<212> PRT

<213> Homo sapiens

<400> 280

Asn Ser Trp Met Asn
1 5

<210>

281

<211>

14

<212>

PRT

<213>

Homo

<400>

281

sapiens

Trp lie Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp lie Gly
15 10

<210>

282

<211>

17

<212>

PRT

<213>

Homo sapiens

<400>

282

Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe Arg
15 10 15

Val

<210> 283
<211> 32
<212> PRT

123

<213> Homo sapiens
<400> 283

Arg Val Thr lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Glu
15 10 15

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
20 25 30

<210> 284

<211> 9

<212> PRT

<213> Homo sapiens

<400> 284

Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr
1 5

<210> 285

<211> 11

<212> PRT

<213> Homo sapiens

<400> 285

Trp Gly Gin Gly Thr Leu Val Thr Val Ser Ser
15 10

<210> 286

<211> 1572

<212> DNA

<213> Homo sapiens

<400> 286

atggactgga cctggaggtt cctctttgtg gtggcagcag ctacaggtgt ccagtcccag 60

gtgcagctgg tgcagtctgg acctgaggtg aagaagcctg gggcctcagt gaaggtctcc 12 0

tgcaaggctt ctggatacac cttcaccaac tcctggatga actgggtgag gcagaggcct 180

ggaaagggtc ttgagtggat tggacggatt tatcctggag atggagaaac tatctacaat 240

gggaaattca gggtcagagt cacgattacc gcggacgaat ccacgagcac agcctacatg 3 00

caactgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag aggctatgat 360

gattactcgt ttgcttactg gggccaggga accacggtca ccgtctcttc aggtggtggt 420

ggatccggag gtggtggatc gggtggtgga ggatcggata ttgtgatgac tcagtctcca 480

ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtaagagt 540

124

ctcctgcata gtaatggcaa cacttacttg tattggttcc tgcagaagcc agggcagtct 600

ccacagctcc tgatctatcg gatgtccaac cttgcctcag gggtccctga caggttcagt 660

ggcagtggat caggcacaga ttttacactg aaaatcagca gagtggaggc tgaggatgtt 72 0

ggggtttatt actgcatgca acatatagaa tatcctttta cgttcggcca agggaccaaa 780

ctggaaatca aaggaggtgg tggatcgggt ggtggtggtt cgggaggcgg tggatcgcag 84 0

gtgcagctgg tgcagtctgg acctgaggtg aagaagcctg gggcctcagt gaaggtctcc 900

tgcaaggctt ctggatacac cttcaccaac tcctggatga actgggtgag gcagaggcct 960

ggaaagggtc ttgagtggat tggacggatt tatcctggag atggagaaac tatctacaat 1020

gggaaattca gggtcagagt cacgattacc gcggacgaat ccacgagcac agcctacatg 1080

caactgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag aggctatgat 1140

gattactcgt ttgcttactg gggccaggga accacggtca ccgtctcttc aggtggtggt 1200

ggatccggag gtggtggatc gggtggtgga ggatcggata ttgtgatgac tcagtctcca 1260

ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtaagagt 1320

ctcctgcata gtaatggcaa cacttacttg tattggttcc tgcagaagcc agggcagtct 1380

ccacagctcc tgatctatcg gatgtccaac cttgcctcag gggtccctga caggttcagt 1440

ggcagtggat caggcacaga ttttacactg aaaatcagca gagtggaggc tgaggatgtt 1500

ggggtttatt actgcatgca acatatagaa tatcctttta cgttcggcca agggaccaaa 1560

ctggaaatca aa 1572

<210> 287
<211> 524
<212> PRT
<213> Homo sapiens

<400> 287

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly

Val Gin Ser Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys

Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
35 40 45

125

Thr Asn Ser Trp Met Asn Trp Val Arg Gin Arg Pro Gly Lys Gly Leu
50 55 60

Glu Trp lie Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn
65 70 75 80

Gly Lys Phe Arg Val Arg Val Thr lie Thr Ala Asp Glu Ser Thr Ser
85 90 95

Thr Ala Tyr Met Gin Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
100 105 110

Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly
115 120 125

Gin Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
130 135 140

Gly Gly Ser Gly Gly Gly Gly Ser Asp He Val Met Thr Gin Ser Pro
145 150 155 160

Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser He Se"r Cys Arg
165 170 175

Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp
180 185 190

Phe Leu Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu lie Tyr Arg Met
195 200 205

Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser
210 215 220

Gly Thr Asp Phe Thr Leu Lys He Ser Arg Val Glu Ala Glu Asp Val
225 230 235 240

Gly Val Tyr Tyr Cys Met Gin His He Glu Tyr Pro Phe Thr Phe Gly
245 250 255

Gin Gly Thr Lys Leu Glu He Lys Gly Gly Gly Gly Ser Gly Gly Gly
260 265 270

Gly Ser Gly Gly Gly Gly Ser Gin Val Gin Leu Val Gin Ser Gly Pro

126

275 280 285

Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
290 295 300

Gly Tyr Thr Phe Thr Asn Ser Trp Met Asn Trp Val Arg Gin Arg Pro
305 310 315 320

Gly Lys Gly Leu Glu Trp lie Gly Arg lie Tyr Pro Gly Asp Gly Glu
325 330 335

Thr lie Tyr Asn Gly Lys Phe Arg Val Arg Val Thr lie Thr Ala Asp
340 345 350

Glu Ser Thr Ser Thr Ala Tyr Met Gin Leu Ser Ser Leu Arg Ser Glu
355 360 365

Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe
370 375 380

Ala Tyr Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
385 390 395 400

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp lie Val Met
405 410 415

Thr Gin Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser
420 425 430

lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr
435 440 445

Tyr Leu Tyr Trp Phe Leu Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu
450 455 460

He Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser
465 470 475 480

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys He Ser Arg Val Glu
485 490 495

Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His He Glu Tyr Pro
500 505 510

127

Phe Thr Phe Gly Gin Gly Thr Lys Leu Glu lie Lys
515 520

<210> 288

<211> 354

<212> DNA

<213> Homo sapiens

<400> 288

caggtgcagc

tggtgcagtc

tggacctgag

gtgaagaagc

ctggggcctc

agtgaaggtc

60

tcctgcaagg

cttctggata

caccttcacc

aactcctgga

tgaactgggt

gaggcagagg

120

cctggaaagg

gtcttgagtg

gattggacgg

atttatcctg

gagatggaga

aactatctac

180

aatgggaaat

tcagggtcag

agtcacgatt

accgcggacg

aatccacgag

cacagcctac

240

atgcaactga

gcagcctgag

atctgaggac

acggccgtgt

attactgtgc

gagaggctat

300

gatgattact

cgtttgctta

ctggggccag

ggaaccacgg

tcaccgtctc

ttca

354

<210> 289

<211> 118

<212> PRT

<213> Homo sapiens

<400> 289

Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
15 10 15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser
20 25 30

Trp Met Asn Trp Val Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe
50 55 60

Arg Val Arg Val Thr lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80

Met Gin Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95

Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr

128

100 105 110

Thr Val Thr Val Ser Ser
115

<210> 290

<211> 336

<212> DNA

<213> Homo sapiens

<400> 290

gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg 120

ttcctgcaga agccagggca gtctccacag ctcctgatct atcggatgtc caaccttgcc 180

tcaggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 24 0

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaacatat agaatatcct 300

tttacgttcg gccaagggac caaactggaa atcaaa 336

<210> 291

<211> 112

<212> PRT

<213> Homo sapiens

<400> 291

Asp lie Val Met Thr Gin Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
15 10 15

Glu Pro Ala Ser He Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Leu Gin Lys Pro Gly Gin Ser
35 40 45

Pro Gin Leu Leu He Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys He
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

129

He Glu Tyr Pro Phe Thr Phe Gly Gin Gly Thr Lys Leu Glu He Lys
100 105 110

<210> 292

<211> 1572

<212> DNA

<213> Homo sapiens

<400> 292

atggactgga cctggaggtt cctctttgtg gtggcagcag ctacaggtgt ccagtcccag 60

gtgcagctgg tgcagtctgg acctgaggtg aagaagcctg gggcctcagt gaaggtctcc 12 0

tgcaaggctt ctggatacac cttcaccaac tcctggatga actgggtgag gcagaggcct 180

ggaaagggtc ttgagtggat tggacggatt tatcctggag atggagaaac tatctacaat 240

gggaaattca gggtcagagt cacgattacc gcggacgaat ccacgagcac agcctacatg 300

gagctgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag aggctatgat 3 60

gattactcgt ttgcttactg gggccaggga accacggtca ccgtctcttc aggtggtggt 420

ggatccggag gtggtggatc gggtggtgga ggatcggata ttgtgatgac tcagtctcca 480

ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtaagagt 540

ctcctgcata gtaatggcaa cacttacttg tattggttcc agcagaagcc agggcaggct 600

ccacggctcc tgatctatcg gatgtccaac cttgcctcag gggtccctga caggttcagt 660

ggcagtggat caggcacagc ttttacactg aaaatcagca gagtggaggc tgaggatgtt 72 0

ggggtttatt actgcatgca acatatagaa tatcctttta cgttcggcca agggaccaaa 780

ctggaaatca aaggaggtgg tggatcgggt ggtggtggtt cgggaggcgg tggatcgcag 84 0

gtgcagctgg tgcagtctgg acctgaggtg aagaagcctg gggcctcagt gaaggtctcc 900

tgcaaggctt ctggatacac cttcaccaac tcctggatga actgggtgag gcagaggcct 960

ggaaagggtc ttgagtggat tggacggatt tatcctggag atggagaaac tatctacaat 102 0

gggaaattca gggtcagagt cacgattacc gcggacgaat ccacgagcac agcctacatg 1080

gagctgagca gcctgagatc tgaggacacg gccgtgtatt actgtgcgag aggctatgat 1140

gattactcgt ttgcttactg gggccaggga accacggtca ccgtctcttc aggtggtggt 1200

ggatccggag gtggtggatc gggtggtgga ggatcggata ttgtgatgac tcagtctcca 1260

ctctccctgc ccgtcacccc tggagagccg gcctccatct cctgcaggtc tagtaagagt 1320

ctcctgcata gtaatggcaa cacttacttg tattggttcc agcagaagcc agggcaggct 1380

ccacggctcc tgatctatcg gatgtccaac cttgcctcag gggtccctga caggttcagt 1440

130

ggcagtggat caggcacagc ttttacactg aaaatcagca gagtggaggc tgaggatgtt 1500
ggggtttatt actgcatgca acatatagaa tatcctttta cgttcggcca agggaccaaa 1560
ctggaaatca aa - 1572

<210> 293

<211> 524

<212> PRT

<213> Homo sapiens

<400> 293

Met Asp Trp Thr Trp Arg Phe Leu Phe Val Val Ala Ala Ala Thr Gly
15 10 15

Val Gin Ser Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys
20 25 30

Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe
35 40 45

Thr Asn Ser Trp Met Asn Trp Val Arg Gin Arg Pro Gly Lys Gly Leu
50 55 60

Glu Trp lie Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn
65 70 75 80

Gly Lys Phe Arg Val Arg Val Thr lie Thr Ala Asp Glu Ser Thr Ser
85 90 95

Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val
100 105 110

Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly
115 120 125

Gin Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
130 135 140

Gly Gly Ser Gly Gly Gly Gly Ser Asp He Val Met Thr Gin Ser Pro
145 150 155 160

Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser He Ser Cys Arg
165 170 175

131

Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Tyr Trp
180 185 190

Phe Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu He Tyr Arg Met
195 200 205

Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser
210 215 220

Gly Thr Ala Phe Thr Leu Lys He Ser Arg Val Glu Ala Glu Asp Val
225 230 235 240

Gly Val Tyr Tyr Cys Met Gin His He Glu Tyr Pro Phe Thr Phe Gly
245 250 255

Gin Gly Thr Lys Leu Glu He Lys Gly Gly Gly Gly Ser Gly Gly Gly
260 265 270

Gly Ser Gly Gly Gly Gly Ser Gin Val Gin Leu Val Gin Ser Gly Pro
275 280 285

Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser
290 295 300

Gly Tyr Thr Phe Thr Asn Ser Trp Met Asn Trp Val Arg Gin Arg Pro
305 310 315 320

Gly Lys Gly Leu Glu Trp He Gly Arg He Tyr Pro Gly Asp Gly Glu
325 . 330 335

Thr He Tyr Asn Gly Lys Phe Arg Val Arg Val Thr He Thr Ala Asp
340 345 350

Glu Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu
355 360 365

Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Tyr Asp Asp Tyr Ser Phe
370 375 380

Ala Tyr Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly
385 390 395 400

132

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp lie Val Met
405 410 415

Thr Gin Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser
420 425 430

lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser Asn Gly Asn Thr
435 440 445

Tyr Leu Tyr Trp Phe Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu
450 455 460

lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro Asp Arg Phe Ser
465 470 475 480

Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys lie Ser Arg Val Glu
485 490 495

Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His lie Glu Tyr Pro
500 505 510

Phe Thr Phe Gly Gin Gly Thr Lys Leu Glu lie Lys
515 520

<210> 294

<211> 354

<212> DNA

<213> Homo sapiens

<400> 294

caggtgcagc tggtgcagtc tggacctgag gtgaagaagc ctggggcctc agtgaaggtc 60

tcctgcaagg cttctggata caccttcacc aactcctgga tgaactgggt gaggcagagg 120

cctggaaagg gtcttgagtg gattggacgg atttatcctg gagatggaga aactatctac 180

aatgggaaat tcagggtcag agtcacgatt accgcggacg aatccacgag cacagcctac 240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggctat 300

gatgattact cgtttgctta ctggggccag ggaaccacgg tcaccgtctc ttca 354

<210> 295

<211> 118

<212> PRT

<213> Homo sapiens

133

<400> 295

Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
15 10 15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asn Ser
20 25 30

Trp Met Asn Trp Val Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp lie
35 40 45

Gly Arg lie Tyr Pro Gly Asp Gly Glu Thr lie Tyr Asn Gly Lys Phe
50 55 60

Arg Val Arg Val Thr lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65 70 75 80

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95

Ala Arg Gly Tyr Asp Asp Tyr Ser Phe Ala Tyr Trp Gly Gin Gly Thr
100 105 110

Thr Val Thr Val Ser Ser
115

<210> 296

<211> 336

<212> DNA

<213> Homo sapiens

<400> 296

gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60

atctcctgca ggtctagtaa gagtctcctg catagtaatg gcaacactta cttgtattgg 120

ttccagcaga agccagggca ggctccacgg ctcctgatct atcggatgtc caaccttgcc 180

tcaggggtcc ctgacaggtt cagtggcagt ggatcaggca cagcttttac actgaaaatc 240

agcagagtgg aggctgagga tgttggggtt tattactgca tgcaacatat agaatatcct 300

tttacgttcg gccaagggac caaactggaa atcaaa 336

<210> 297
<211> 112
<212> PRT

134

<213> Homo sapiens
<400> 297

Asp lie Val Met Thr Gin Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
15 10 15

Glu Pro Ala Ser lie Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser
20 25 30

Asn Gly Asn Thr Tyr Leu Tyr Trp Phe Gin Gin Lys Pro Gly Gin Ala
35 40 45

Pro Arg Leu Leu lie Tyr Arg Met Ser Asn Leu Ala Ser Gly Val Pro
50 55 60

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Lys He
65 70 75 80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gin His
85 90 95

He Glu Tyr Pro Phe Thr Phe Gly Gin Gly Thr Lys Leu Glu He Lys
100 105 110

<210> 298

<211> 30

<212> PRT

<213> Homo sapiens

<400> 298

Gin Val Gin Leu Val Gin Ser Gly Pro Glu Val Lys Lys Pro Gly Ala
15 10 15

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
20 25 30

<210>

299

<211>

14

<212>

PRT

<213>

Homo

<400>

299

Trp Val Arg Gin Arg Pro Gly Lys Gly Leu Glu Trp He Gly
15 10

\

135

<210> 300

<211> 32

<212> PRT

<213> Homo sapiens

<400> 300

Arg Val Thr lie Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr Met Gin
15 10 15

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg
20 25 30

<210> 301

<211> 11

<212> PRT

<213> Homo sapiens

<400> 301

Trp Gly Gin Gly Thr Thr Val Thr Val Ser Ser
15 10

<210> 302

<211> 23

<212> PRT

<213> Homo sapiens

<400> 302

Asp lie Val Met Thr Gin Ser Pro Leu Ser Leu Pro Val Thr Pro Gly
15 10 15

Glu Pro Ala Ser lie Ser Cys
20

<210> 303

<211> 15

<212> PRT

<213> Homo sapiens

<400> 303

Trp Phe Leu Gin Lys Pro Gly Gin Ser Pro Gin Leu Leu lie Tyr
15 10 15

<210> 304
<211> 32
<212> PRT

136

<213> Homo sapiens
<400> 304

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
15 10 15

Leu Lys lie Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
20 25 30

<210>

305

<211>

10

<212>

PRT

<213>

Homo

sapiens

<400>

305

Phe Gly Gin

Gly Thr

1

<210>

306

<211>

32

<212>

PRT

<213>

Homo

sapiens

<400>

306

Arg Val

. Thr

lie Thr

1

5

Leu Ser Ser

Leu Arg

20

<210>

307

<211>

15

<212>

PRT

<213>

Homo

sapiens

10

10 15

25 30

<400> 307

Trp Phe Gin Gin Lys Pro Gly Gin Ala Pro Arg Leu Leu He Tyr
15 10 15

<210> 308

<211> 32

<212> PRT

<213> Homo sapiens

<400> 308

137

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr
15 10 15

Leu Lys lie Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys
20 25 30